Pharmacology and Toxicology is a subject that imposes a great responsibility on the veterinary and medical practitioner in their day to day clinical practice. Conceptualizing the concepts and making them at ease to the budding vets is the need of the hour. The central dogma of revisiting the concepts lies well with the practices of the objective type questions to help individuals in attaining a great success in their academic and professional pursuit. This book will provide a comprehensive detailing of the subject and build their analytical approach to mitigate the academic challenges in the competitive exams viz. 

Q1. The exit of drug from C.S.F. irrespective of its entry is by Passive diffusion Filtration Facilitated diffusion All of the above Q2. The number of half-lives required to reach 99% of steady state concentration is 3.3 4.4 5.5 6.6 Q3. The receptor concept was first introduced by J.N. Langley in 1878 Simonis in 1964 Paul Ehrlich in 1926 Walksman in 1826

Q1. Resistance in tetracycline is due to mutational changes in Tet A gene Kat G Par C par E Inh A Q2. Single step mutation can be seen in Erythromycin Tetracycline Chloramphenicol Rifampicin Q3. Multistep mutation is observed in Streptomycin Rifampicin Both A and C Tetracycline

Q1. The nitrogen atom of amino group in basic structure of sulfonamide is designated as N1 N2 N3 N4 Q2. Trimethoprim produces synergistic action by interfering the synthesis of Dihydrofolic acid from tetrahydrofolic acid Tetrahydrofolic acid from dihydrofolic acid mRNA from DNA tRNA from DNA Q3. An ophthalmic sulfonamide is Sulfaguinidine Sulfadimidine Sulfadimethoxine Sodium sulfacetamide

Q1. Glucuronide conjugation occurs in the compounds with following functional groups: Hydroxyl Carboxyl Amino All above Q2. Which of the following is not a chelating agent: Dimercaprol Penicillamine Dimethyl sulfoxide Ca-EDTA Q3. Most appropriate treatment of acute organophosphate toxicity: Atropine alone 2-PAM alone Atropine + 2-PAM Sod. Thiosulphate alone

Q1. Penicillins disrupt the formation of following peptide bond during its antibacterial action on bacteria: D-alanine-D-aspartate D-alanine- D-glutamate D-Glycine-D-alanine D-alanine-D-alanine Q2. In E.coli, topoisomerase IV, the target enzyme of the quinolones is encoded by the genes parC and parE gyrA and gyrB par C and gyr A parE and gyrB Q3. Streptomycin interferes in protein synthesis by inhibiting the start codon AUG AAU UUA AGUa

Q1. The exit of drug from C.S.F. irrespective of its entry is by: Passive diffusion Filtration Facilitated diffusion All of the above. Q2. The number of half-lives required to reach 99% of steady state concentration is: 3.3 4.4 5.5 6.6 Q3. The receptor concept was first introduced by: J.N. Langely in 1878 Simonis in 1964 Paul Ehrlich in 1926 Wakcsman in 1826

Q1. Alpha naphthyl thiourea is less toxic In an empty stomach With oily food Full stomach Not affected Q2. A rodenticide that blocks tricarboxylic acid cycle by competitive inhibition of the enzyme aconitase Fluoroacetamide Pindone Chloralose All the above Q3. ANTU is less toxic in an empty stomach a) In an empty stomach it will irritate the stomach wall resulting in vomiting and throwing away the poison and hence no toxicity. Absorb only with fatty materials Immediate absorption and detoxification All the above None of the above

Q1. Halothane is metabolized in to Trifluoracetic acid Inorganic chloride Bromine All the above Q2. Psychomotor stimulants causes Excitement Relieve fatigue Increase motor activity All the above Q3. Repeated administration of barbiturate causes Tolerance Drug dependence Toxicity All the above

PART-A 1. Indicate True/False for the following Super infection phenomenon is common with antibiotics that are given as depot preparation.______ A combination of penicillin and chlortetracycline leads to antagonism of antimicrobial activity.______ Bactericidal drugs act most effectively on toxins librated by organism. Most of the laboratory sensitivity tests are conducted at a pH of 4-5.______

Q1. Which of the following is semisynthetic product: Chlortetracycline Chloramphenicol Tetracycline Oxytetracycline Q2. Natural source of amphotericin B is: Streptomyces aureofaciencs Streptomyces nodosus Streptomyces erythreus Streptomyces venezuelse Q3. Following is /are mitotic inhibitor Paclitaxel Griseofulvin Vinblastine All of the above

PART-A Q1. Elimination of drug is studied under? Pharmacokinetics Pharmacometrics Toxicodynamics Toxicoelimination Q2. Serpentine receptor is characterized by 7 Transmembrane loop Petals of lilly like structure Zinc fingers JAK STAT Q3. Status epilepsy is treated best with lorazepm/diazepam Per rectal Intravenous Intramuscular Oral