RNA Therapeutics, RNA Drug Discovery, Computational Biology, Bioinformatics, RNA Therapeutic Design, Artificial Intelligence in Drug Discovery, Machine Learning in RNA Research, RNA Structure Prediction, RNA Folding, RNA Databases, siRNA Therapeutics, miRNA Therapeutics, mRNA Therapeutics, Molecular Docking, Molecular Dynamics, Systems Biology, Multi-Omics Integration, Synthetic Biology, RNA Delivery Systems, Personalized RNA Medicine
Computational and Systems Approaches in RNA Therapeutic Design presents an interdisciplinary approach to the rapidly developing field of RNA-based medicine, bringing together RNA biology, bioinformatics, computational biology, artificial intelligence, machine learning, systems biology and drug discovery. Computational methods are increasingly important for RNA therapeutic development, including RNA structure prediction, target identification, molecular modelling, sequence design and delivery optimization.
The book begins with the fundamentals of RNA therapeutics, RNA structure, function and stability, before progressing to computational tools for RNA folding and structure prediction and databases supporting RNA research. It explores AI and machine learning in RNA drug discovery, in-silico design of siRNA, miRNA and mRNA therapeutics, molecular docking and molecular dynamics, and systems-level analysis of RNA regulatory networks.
Chapter 1. Overview of RNA Therapeutics: From Concept to Clinic
Sarmita S. Jana, Vasundhara Raina, Singh Khushi Sanjeev, Joshua C. Varughese, Rishabh Garg
Chapter 2. RNA Biology: Structure, Function, and Stability
Hansa Gul, Haris Ahmed Khan, Nouman Ahmad, Muhammad Nauman Khan, Muhammad Iqbal, Mujeeb ur Rahman
Chapter 3. Computational Tools for RNA Structure Prediction and Folding in Therapeutics
Chapter 4. Databases and Repositories for RNA Therapeutics
Uchakankhi Kashyap, Hemanga Kashyap, Nima D. Namsa
Chapter 5. Machine Learning and Artificial Intelligence in RNA Drug Discovery
Bhavya Mudgal, Poornika Sah, Sugam Gupta, Devvret Verma, Kumud Pant, Mohd Tariq, Saleha Diwan, Ayush Madan
Chapter 6. In Silico Design of siRNA, miRNA, and mRNA Therapeutics
Anshul, Sugam Gupta, Devvret Verma, Kumud Pant, Deeksha Kumari, Debasis Mitra
Chapter 7. Molecular Docking and Dynamics in RNA-Targeted Drug Development
Anu Radha Pathania, Aashvi Panchal, Imran Hasan, Anshita, Neha Govind Rao
Chapter 8. Systems Biology Models in RNA Regulatory Networks
Anshul, Devvret Verma, Kumud Pant, Deeksha Kumari, Debasis Mitra, Mohd Tariq, Mohammedtarik Saiyad, Ayush Madan
Chapter 9. Network Biology of RNA Interactions: Deciphering Pathways and Molecular Crosstalk in Disease
Hansa Gul, Mamoona Uzma Kalsoom, Muhammad Iqbal, Muhammad Nauman Khan
Chapter 10. Multi-Omics Integration for RNA Therapeutic Target Identification
Chapter 11. Predictive Modeling for RNA-Based Gene Regulation
Rishabh Garg, Ayush Madan, Mohd Tariq
Chapter 12. Synthetic Biology and Systems-Level RNA Circuit Design
Chapter 13. RNA Delivery Systems Including Lipid Nanoparticles, Exosomes, and Polymers for Therapeutic Application
Chapter 14. Computational Pharmacokinetics and Toxicity Modelling of RNA Drugs
Bishakha Thakur, Ramandeep Saini, Isha Agarwal, Shreya Priyam, Ayush Madan
Chapter 15. Personalized Medicine and RNA Therapeutic Optimization
Chapter 16. Case Studies: mRNA Vaccines and Beyond
Sameel Hassan, Amna Khalil, Muhammad Anas, Anwer Usma, Javed Iqbal, Banzeer Ahsan Abbasi
Chapter 17. Ethical and Regulatory Aspects in RNA Therapeutics
Chapter 18. Data-Driven Innovation in RNA Drug Development
Chapter 19. The Future of AI and Systems Medicine in RNA Therapeutics
Muhammad Nauman Khan, Muhammad Iqbal, Hansa Gul, Zahida Nasreen, Alevcan Kaplan, Mukul Jain, Mohd Tariq
