
toxicology, agricultural chemicals, drugs, environmental pollution, natural toxicants, phytotoxins, mycotoxins, clinical settings, undergraduate, postgraduate, heavy metal toxicology, pesticide toxicology, microbial toxicology, zootoxicology, radiation hazards, environmental toxicology
Toxicology, in recent years, has acquired greater importance than ever before because of increasing and indiscriminate use of farm chemicals and drugs accompanied by rapid degrading impact of environmental pollution on health of animals. The indiscriminate feeding habits of domestic animals especially in developing countries make them more prone to the impact of natural toxicants like Phytotoxins and Mycotoxins. Toxicology has been recognized as a separate discipline in all sciences both at undergraduate and post graduate levels for the last four decades and lot of emphasis has been given on its teaching, research and practical utility from clinical point of view. This book was written with two goals in mind (i) to provide a textbook for students that would supplement their classroom instruction and (ii) to supply a valuable aid to practioneThe book has been prepared in a most comprehensive manner with up to date references which offers invaluable, clinically oriented guidance on numerous potentially toxic substances. In addition, to covering traditional and non-traditional areas of toxicology it provides a wealth of quick reference charts and tables that gives vital information at your finger tips.
Notice Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge; changes in treatment and drug therapy are required. The author and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the author nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs.
Definitions Toxicology: Knowledge (or science) of poisons, including their chemical properties, identification, biological effects, and the treatment of conditions they cause. Poison: Any solid, liquid, or gas that, when introduced into or applied to the body, can interfere with the life processes of cells of the organism - by its own inherent chemical properties - without acting mechanically and regardless of temperature.
Arsenic General Information 1. Exists in elemental form (-3), trivalent As+3 and pentavalent As+5 oxidation states 2. Arsenic is an essential element for rats, chicks, mini-pigs and goats 3. The second most important pollutant for livestock. Source 1. Inorganic form is used in paints. 2. Pasture near smelters may be contaminated. 3. Industrial effluents released into nearby water body 4. Insecticides (Arsenic trioxide, lead arsenate). 5. Herbicides (Sodium arsenite, lead arsenate)
Nitrate - Nitrite Poisoning Sources Accidental ingestion/grazing of Plants which are Nitrate accumulators
Introduction Plants are the main source of nutrition to farm animals for their maintenance and production. But, under certain conditions, plants intoxicate farm animal life due to the presence of some deleterious substances called phytotoxins. Such plants include a variety of fodder plants (Jowar, wheat straw, Lucerne), grasses (Millet grass), ornamental or fencing plants (Crotons, Nerium sps) and weeds (Tribulis) in the farm premises.
Introduction The word mycotoxin is derived from myco, meaning mold and toxin, a poison. A great number of mold metabolites have been identified as mycotoxins. Thus mycotoxins are secondary fungal metabolites (i.e., metabolites not essential to the normal growth and reproduction of the fungus) which cause pathologic, physiologic, and/or biochemical lesions in other species (may include animals, plants, other microbes, etc.).
Introduction In the thirst of modernization and industrialization man has contributed pollution to the life and ecology of plants, animals and microbes. Increased demand for food and fiber has lead to the chemicalization of agriculture and we have reached on such a stage that modern agriculture is dependent on high yielding varieties, which can only be grown under the influence of fertilizers and pesticides. Pesticides are the man made chemicals which are being used to produce enough cheap food. In India, 90,000 MT of technical grade pesticides are used annually to control pests and plant diseases. The pesticides are classified as insecticides, fungicides, weedicides, herbicides, nematodicides and rodenticides; of which insecticides constitutes 77% of the total pesticides used in different agricultural and animal husbandry practices and in public health operations.
Introduction A toxin (Greek: ôïîéêüí, toxikon, lit. (poison) for use on arrows) is a poisonous substance produced by living cells or organisms that is active at very low concentrations. Toxins can be small molecules, peptides, or proteins and are capable of causing disease on contact or absorption with body tissues by interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their severity, ranging from usually minor and acute (as in a bee sting) to almost immediately deadly (as in botulinum toxin)
Introduction The major conditions described under this heading are as follows : 1. Snakebite 2. Scorpion bite 3. Black widow spider sting 4. Toad poisoning Snake Bite Poisonous snakes mainly belong to three categories
Introduction Chemical warfare involves using the toxic properties of chemical substances to kill, injure or incapacitate an enemy. Chemical warfare is different from the use of conventional weapons or nuclear weapons because the destructive effects of chemical weapons are not primarily due to any explosive force. The offensive use of living organisms (such as anthrax) is considered to be biological warfare rather than chemical warfare; the use of nonliving toxic products produced by living organisms (e.g., toxins such as botulinum toxin, ricin, or saxitoxin) is considered chemical warfare under the provisions of the Chemical Weapons Convention. Under this Convention, any toxic chemical, regardless of its origin, is considered as a chemical weapon unless it is used for purposes that are not prohibited (an important legal definition, known as the General Purpose Criterion)
Definition Radiation poisoning, also called “radiation sickness” or a “creeping dose” is a form of damage to organ tissue due to excessive exposure to radiation. The term is generally used to refer to acute problems caused by a large dosage of radiation in a short period, though this also has occurred with long term exposure to low level radiation. Many of the symptoms of radiation poisoning occur as ionizing radiation interferes with cell division. The clinical name for “radiation sickness” is acute radiation syndrome. A short exposure can result in acute radiation syndrome; chronic radiation syndrome requires a prolonged high level of exposure. A chronic radiation syndrome does exist but is very uncommon;
Introduction Pollution is the introduction of contaminants into an environment that causes instability, disorder, harm or discomfort to the physical systems or living organisms they are in. Pollution can take the form of chemical substances, or energy, such as noise, heat, or light energy. Pollutants, the elements of pollution, can be foreign substances or energies, or naturally occurring; when naturally occurring, they are considered contaminants when they exceed natural levels. Sometimes the term pollution is extended to include any substance when it occurs at such unnaturally high concentration within a system that it endangers the stability of that system. For example, water is innocuous and essential for life, and yet at very high concentration, it could be considered a pollutant.
References A. F. Stone, K. C. Binnington, M. Gauci, J. H. Aylward (1989). “Tick/host interactions for Ixodes holocyclus: Role, effects, biosynthesis and nature of its toxic and allergenic oral secretions”. Experimental and Applied Acarology 7 (1): 59–69. Ahn.,J.H., Robertson, B.M., Elliot, R., Gutterridge, R.C. and Ford C.W. (1989). Quality Assessment of Tropical Browse legumes: Tannin content and protein degradation. Animal Feed Science and Technology 27: 147–156. Air Pollution, Heart Disease and Stroke from the website of the American Heart Organization January 5, 2008. Allison, M.J., Hammond, A.C. and Jones, R.J. (1990). Detection of ruminal bacteria that degrade toxic dihydroxy pyridine compounds produced from mimosine. Applied and Environmental Microbiology 56: 590–594. Anonymous (1993). Surveillance of food contaminants in India-Report of an ICMR task force study (Part-I) New-Delhi, pp. 15-40. Bamualin, A., Jones, R.J. and Murray, R.M. (1980). Nutritive value of tropical browse legumes in the dry season. Proceedings of the Australian Society of Animal Production 13: 229–232.
Abbreviations
Notice
Chapter-1 : General Toxicology
Definitions
Branches of toxicology
Classification of toxicants/poisons
Factors influencing toxicity/poisoning
Toxicokinetics
Toxicodynamics
Collection and dispatch of specimens in toxicological causes
Diagnosis of poisoning conditions
General line of treatment of poisoning in animals
Systemic antidotes-Dosage & method of treatment (Large Animals)
Systemic antidotes-Dosage & method of treatment (Small Animals)
Toxicity testing methods
Chapter-2 : Heavy Metal Toxicology
Arsenic
Mercury
Copper
Lead (Plumbism)
Selenium
Molybdenum
Cadmium
Zinc
Chapter-3 : Non-Metal Toxicology
Nitrate - Nitrite poisoning
Salt poisoning
Fluoride toxicosis (Fluorosis)
Urea (Ammonia) poisoning
Acids and Alkali poisoning
Clinical signs and lesions
Chapter-4 : Phytotoxicology
Introduction
Classification of phytotoxins
Cyanide
Abrus precatorius
Strychnos nuxvomica
Ricinus communis
Nicotiana spp.
Lathyrus spp.
Cotton (Gossypium spp.)
Crotalaria spp.
Lantana spp.
Datura stramonium
Solanum spp.
Amaranthus spp.
Nerium spp.
Pteridium aquilinum
Senecio spp.
Goitrogenic substances
Anti-nutritional factors, the potential risks of toxicity and methods to alleviate them
Chapter-5 : Mycotoxicoses
Introduction
Classification
Aflatoxins
Rubratoxins
Ochratoxins
Trichothecene mycotoxins
Zearalenone and zearalenol
Ergot alkaloids
Festuca arundinacea
Chapter-6 : Pesticide Toxicology
Introduction
Classification of pesticides
Insecticides
Organophosphorus and carbamate insecticides
Organophosphorus-Induced delayed neuropathy (OPIDN)
Pyrethrum (Pyrethrins) and pyrethroids
Rotenone
Amitraz
Herbicides
Paraquat
Polychlorinated biphenyls (PCBS) and Polybrominated biphenyls(PBBS)
Pentachlorophenol
Rodenticides
Anticoagulant rodenticides
Warfarin
Alpha-Naphthyl thiourea (ANTU)
Cholecalciferol Based rodenticides
Zinc phosphide and Aluminum phosphide
Metaldehyde
Fluoroacetate
Chapter-7 : Microbial Toxicology
Introduction
Laboratory detection of toxins
Tetanus
Botulism
Blue-green algae
Chapter-8 : Zootoxicology
Introduction
Snake Bite
Scorpions
Tick paralysis
Toad poisoning
Chapter-9 : Defense Toxicology
Introduction
Chemical warfare agents
Chapter-10 : Radiation Hazards
Definition
Sources of ionizing radiation
Effects of radiation toxicosis
Acute whole body exposure to radiation
Partial body exposure to radiation
Prevention and treatment
Chapter-11 : Environmental Toxicology
Introduction
Air pollution
Toxic gases
Acid rain
Water pollution
References
Appendices
Appendix-1 : Differential diagnosis of poisons based on clinical signs
Appendix-2 : Diagnosis of poisons based on biochemical values
Appendix-3 : Classification of poisons based on systems affected
Appendix-4 : Materials to be sent to the laboratory in various poisoning conditions
Appendix-5 : Industries and principal constituents of effluents
Appendix-6 : List of teratogens and their teratogenic dosage
Appendix-7 : Drugs and toxicants modifying cholinergic neurotransmission
Index
