eChapters

Aplasia/Agenesis

Aplasia or agenesis is absence of any organ (Fig. 9.1).

Hypoplasia

Hypoplasia is failure of an organ/tissue to attain its full size (Fig. 9.1).

Etiology

• Congenital anomalies e.g. hypoplasia of kidneys in calves.

• Inadequate innervation.

• Inadequate blood supply.

• Malnutrition.

• Infections e.g. cerebral hypoplasia in bovine viral diarrhoea.

Calcification

Calcification is the deposition of calcium phosphates and calcium carbonates in soft tissues other than bones and teeth. It may be classified as dystrophic and metastatic calcification.

Dystrophic Calcification

Dystrophic calcification is characterized by the deposits of calcium salts in necrosed tissue of any organ (Fig 8.1).

Etiology /Occurrence

• Necrosis.

• Parasitic infections.

• Tuberculous lesions.

Immunity

Immunity is the resistance of body against extraneous etiological factors of disease, which is afforded by the interaction of chemical, humoral and cellular reactions in body. This is an integral part of the body without, which one cannot think of life. During the process of evolution, nature has provided this defense mechanism in the bodies of all living creatures particularly of higher animals and man, that protects them from physical, chemical and biological threats. It can be classified as natural or paraspecific and acquired or specific immunity.

Natural/paraspecific immunity

There are some species which are resistant to particular diseases due to presence of natural resistance against them e.g. horse, pig, cat are resistant to canine distemper virus; dogs are resistant to feline panleucopenia virus, chickens are resistant to anthrax. Even within species, there is natural resistance that protects some individuals while others are susceptible e.g. Indian deshi cattle Zebu (Bos indicus) is quite resistant to piroplasmosis in comparison to Bos taurus. Besides, there are the mechanisms or barriers in body provided by nature.

Inflammation

Inflammation is a complex process of vascular and cellular alterations that occur in body in response to injury. The term inflammation has been derived from the Latin word inflammare, means to set on fire. Inflammation is considered as an important event in body that activates the existing defense mechanisms in circulating blood to dilute, naturalize or kill the irritant/ causative agent. Thus, it is said that immunity is the resistance of body, while inflammation is the activation of that immunity. It is beneficial to body except when chronic or immune origin. Inflammation starts with sublethal injury and ends with healing.

Etiology

• Any irritant/ injury.

• Bacteria, virus, parasite, fungus etc.

• Trauma. • Physical or chemical injury.

Necrosis

Local death of tissue /cells in living body is known as necrosis, It is characterized by the followings.

• Pyknosis is condensation of chromatin material, nuclei become dark, reduced in size and deeply stained.

• Karyorrhexis is fragmentation of nucleus.

• Karyolysis is dissolution of nucleus into small fragments, basophilic granules/fragments.

• Chromatolysis is lysis of chromatin material.

• Necrobiosis is physiological cell death after completion of its function e.g. RBC after 140 days.

Necrosis is further classified into coagulative, caseative, liquifactive and fat necrosis which are different from apoptosis (Figs. 5.1 to 5.3).

Cloudy Swelling

Swelling of cells occur with hazy appearance due to a mild injury. The cells take more water due to defect in sodium pump leading to swollen mitochondria which gives granular cytoplasmic appearance. It is the first reaction of cell to the mildest injury. Cloudy swelling is a reversible reaction (Figs. 4.1 & 4. 2).

Etiology

• Can be caused by even mildest injury.

• Any factor causing interference with metabolism of the cell like bacterial toxins, fever, diabetes, circulatory disturbances etc.

Macroscopic features

• Organ becomes enlarged and rounded.

• Weight of organ increases.

• Bulging on cut surfaces.

• Amount of fluid increases in organ.

Microscopic features

• Swelling of cells, edges become rounded.

• Increased size of cells.

• Cytoplasm of the cells becomes hazy/cloudy due to increased granularity.

• Can be seen in liver, kidney and muscles.

Congestion/ Hyperemia

Hyperemia is increased amount of blood in circulatory system. It is of two types, active and passive. In active hyperemia blood accumulates in arteries while in passive hyperemia the amount of blood increases in veins (Figs. 3.1. to 3.4).

Etiology

• As a result of inflammation.

• Obstruction of blood vessels.

Macroscopic features

• Organ becomes dark red/cyanotic.

• Size of organ increases.

Etiology

Etiology is the study of cause of disease. It gives precise causal diagnosis of any disease. Broadly, the cause of diseases can be divided into two

a. Intrinsic causes.

b. Extrinsic causes.

Intrinsic Causes

Those causes which determine the type of disease present within an individual over which he has no control. These causes are further divided into following subgroups:

Genus

Specific diseases occur in a particular genus or species of animals. e.g. Hog cholera in pigs, Canine distemper in dogs

Definitions

Pathology

Pathology is the study of the anatomical, chemical and physiological alterations from normal as a result of disease in animals. It is a key subject because it forms a vital bridge between preclinical sciences (Anatomy, Physiology, Biochemistry) and clinical branches of Medicine and Surgery (Fig.1.1). Pathology is derived from the Greek word pathos = disease, logos = study. It has many branches, which are defined as under:

General Pathology

General Pathology concerns with basic alterations of tissues as a result of disease. e.g. fatty changes, thrombosis, amyloidosis, embolism, necrosis (Fig. 1.2).

Systemic Pathology

Systemic Pathology deals with alterations in tissues/organs of a particular system. e.g. respiratory system, genital system etc. (Fig. 1.3).

Key Points

• Animal euthanasia is the act of humanely killing animals, most commonly with injectable drugs.

• Euthanasia techniques vary by species, age, and the health status of the individual animal.

• Death must be confirmed before disposal of any animal remains.

• Animal remains must be disposed of in a legal manner that does not contaminate food sources or the environment.

Introduction

Euthanasia is the act of inducing humane death in an animal by a method that induces rapid loss of consciousness and death with a minimum of pain, discomfort, or distress. Euthanizing agents cause death by three basic mechanisms: (1) direct depression of neurons necessary for life function, (2) hypoxia, and (3) physical disruption of brain activity. Because loss of consciousness resulting from these mechanisms can occur at different rates, the suitability of a particular agent or method will depend on whether an animal experiences distress before loss of consciousness. Unconsciousness, defined as a loss of individual awareness, occurs when the brain’s ability to integrate information is blocked or disrupted. Ideally, euthanasia techniques cause rapid loss of consciousness, followed by cardiac or respiratory arrest and death.

Key Points

• With the aid of microorganisms, ruminants typically use NPN to synthesis proteins for nutritional needs.

• When there is an excess of urea in the body, ammonia is produced excessively, which can be harmful.

• The majority of clinical indicators are neurological in nature, and their severity varies depending on a number of variables.

• Ruminal environment acidification to stop excessive ammonia generation and absorption; symptomatic therapy is advised.

Introduction

In addition to being a widely utilized fertilizer for crops, urea is frequently used in animal feeds as a low-cost protein substitute [1]. The previously mentioned explanations explain the reports of urea toxicity in ruminants. These animals may use non-protein nitrogen (NPN) like urea to create ammonia, which is subsequently used to synthesize proteins that partially meet their nutritional needs. This is made possible by the urease enzyme and ruminal microorganisms. On the other hand, rapid overconsumption of NPN leads to excessive ammonia generation and toxicity. This chapter aims to provide an overview of some of the most frequent causes of urea poisoning, clinical symptoms to watch out for, and associated treatments.

Key Points

• It might be necessary to administer oxygen or perform artificial respiration. Giving tranquilizers is not a good idea.

• Precaution: It's crucial to always follow the label's instructions on how to use pesticides since they provide information on how to do so. Warnings against using on unapproved species or in testing conditions must also be included on labels. A maximum of care should be made to prevent drift or drainage to neighboring fields, pastures, ponds, streams, or other properties outside the treatment area. In no case should amounts larger than those specifically recommended be utilized.

Introduction

It has been determined that a number of plant species are poisonous to animals. These plants not only posed a health risk to humans and animals, but they also significantly reduced cattle productivity. Many plants contain chemicals that can be dangerous or even lethal to animals. The degree of toxicity varies based on the animal species, the quantity of plant material ingested, and the particular poisonous compounds in question. In general, there are two categories of dangerous plants: those that are known to be toxic and contain toxic compounds, and those that are normally non-toxic but can turn hazardous in certain circumstances. Here are some typical plant toxicities, along with information on managing toxicity and clinical signs.

Key Points

• When pesticides, which are chemicals used to manage a pest, impact non-target organisms like humans and animals, it's known as pesticide poisoning.

• Pesticides have the ability to contaminate the surrounding area and the ecosystem.

Introduction

Pesticides are chemical chemicals that are applied to destroy pests. These insecticides have the capacity to contaminate the surrounding area and the ecosystem. Pesticides can also be hazardous to a wide range of other creatures, including fish, birds, beneficial insects, and non-target plants, in addition to having a toxic effect on insects and weeds.

Etiology

Today's society faces several issues due to the overuse of pesticides in fields and food. Products may deteriorate if they are kept in partially filled containers for extended periods of time or exposed, whether intentionally or unintentionally, to high temperatures. It is dangerous to store chemicals anywhere other than their original container since the identification and label instructions are lost. These products can have severe effects on people or animals if they come into unintended touch with them. It can be extremely risky to mix substances or use them in unapproved combinations. In order to increase the efficacy of certain pesticide formulations, such as pyrethrins, pyrethroids, and d-limonene, piperonyl butoxide is added. It lessens the chemical's breakdown in the body of the insect or animal, but it also increases the pesticide's toxicity to both the pest and the host animal.

Key Points

• It is frequently reported that metal, non-metal, and metalloid components cause toxicity in farm animals.

• The type of element causing toxicity affects both the treatment and the clinical indications of toxicity.

• The best course of action for managing toxicity is to treat symptoms f irst, then, if the causal toxin is known, use targeted antidotes.

Introduction

Animal diets contain a variety of environmental components, including metals and non-metals. Certain substances are necessary for the animal and only become poisonous when consumed in excess, while others simply endanger the animal's health. However, a number of variables, including the absorbed dose, the exposure route, the period of exposure (acute versus chronic), and others, affect how toxic the substance is, and these variables must be taken into account when diagnosing, treating, and managing clinical cases. Given the multitude of factors affecting these metals' toxicity. An attempt is made in this chapter to present a streamlined synopsis of the toxicity of metals, non-metals, and metalloid elements that are frequently encountered.

Key Points

• Dogs can be fed a wide variety of chocolate and cocoa-based goods, particularly during holiday seasons, such as candy, cakes, cookies, brownies, and chocolate chips.

• Dogs that eat chocolate usually become very sick, but they also seldom die from it.

Introduction

Caffeine and theobromine are found in chocolate. Dogs' metabolisms of caffeine and theobromine differ from humans'. Because they contain more theobromine and caffeine, darker, bitter chocolates are considered to be more dangerous.

When a dog consumes too much chocolate goods, it can lead to major health problems like seizures, heart failure, and muscular tremors. In extreme situations, the dog may even pass away from cardiac or respiratory failure. Due to the fat and sugar content, it induces vomiting and diarrhoea even in non-toxic doses. Numerous substances found in chocolate are hazardous to animals. Although chocolate poisoning can affect a wide variety of animal species, including dogs, cats, horses, and rodents, it most frequently affects dogs. Theobromine and caffeine are the main harmful ingredients in chocolate. The amount of caffeine and theobromine in chocolate varies with kind. Dogs' metabolism of theobromine and caffeine differs from that of humans. Dogs are more sensitive because of this. Dogs who consume chocolate may become seriously unwell, even though it rarely results in death. When a dog eats too many chocolate-containing foods, such as cakes, cookies, brownies, candies, and chocolate chips, it might become poisoned.

Key Points

• Drug poisonings can be acute or chronic and result in the development of clinical signs and symptoms that may lead to animal disability or death, as well as extreme physiological and/or psychological changes.

• Drugs are substances that are used to prevent, treat, diagnose, and relive disease conditions by changing the physiology and/or psychology of the individual.

• Certain veterinary drugs have a specific antidote to counteract poisoning cases, while other veterinary drugs do not, and supportive therapy is required to counter these poisonings.

• Over-the-counter (OTC) medications, which are defined as human drugs or nutritional supplements that are available without a prescription, have potential risks for use in animals due to their increased toxicity.

Introduction

Many veterinary medications, which are used to treat both animals and birds, have the potential to poison the species to whom they are provided. These medications' toxic effects are mostly caused by giving them to the wrong species, at the wrong doses, or in the wrong combinations of medications. Certain medication poisonings can be identified due to patient individuality and eccentricities. As a result, there are many cases of these poisonings. This chapter discusses the poisoning caused by frequently and carelessly used veterinary medications, such as the toxicity of antibiotics and antibacterials, the toxicity of antiparasitic drugs, the toxicology of analgesics, the toxicity of cough treatments, the toxicity of the digestive system, the toxicity of vitamins, and the toxicity of topical preparations.

Key Points

• Electrolyte Imbalance: Regularly monitor and rectify imbalances in potassium, sodium, and other electrolytes dependent on the individual situation. Prompt management requires early detection of metabolic emergencies.

• Fluid Management: To restore intravascular volume and prevent dehydration in many metabolic emergencies, adequate fluid replacement is essential.

• Continuous monitoring of vital signs, laboratory values, and clinical status is essential for evaluating the efficacy of interventions and making necessary modifications.

Introduction

A class of disorders known as "metabolic emergencies" affect metabolism and physiology abnormally in both congenital and acquired forms. Among these ailments are endocrine disorders, thyrotoxicosis, inborn metabolic inefficiencies, and illnesses linked to electrolyte imbalances. Hypercalcemia, hyponatremia, hypoglycemia, hyperglycemia, and diabetic ketoacidosis, as well as hyperuricemia, hyperuremia, and hypercreatininemia due to renal failure, lactic acidosis, hyperammoniemia, and adrenal failure, are metabolic emergencies that pose a life-threatening risk.

Key Points

• The most commonly cystitis and pyelonephritis occurs in farm and companion animals after parturition.

• Hematuria, pyuria, and stranguria are common presenting clinical symptoms;

• In acute situations, a prolonged course of treatment (two to four weeks) with the administration of the proper antimicrobials is usually successful.

Introduction

Both farm animals and companion animals frequently suffer from urinary infections, which are difficult to diagnose. In cows, urine testing is more helpful in excluding the illness if it shows any pus or germs (in females), and f inding the urethral calculus that is causing the urinary obstruction can be done by palpating the bladder using a rectum examination and palpating the urethral tube (in males). Because of the shorter urethra in females and the associated uterine infection that occurs during or after parturition, females are more likely to get urinary tract infections.

Key Points

• Dogs exhibit respiratory distress symptoms more frequently than cats.

• Respiratory distress might have overt or covert clinical symptoms.

• The thorax and belly move paradoxically in cases of severe respiratory distress.

• Immediate intubation is the first step in managing a respiratory emergency: opening the airway.

Introduction

The telltale symptoms of "oxygen hunger" include tachypnea, stretched head and neck, abducted elbows, flare of the nares, cyanosis, open-mouth breathing, anxiety, and inability to lie down or relax. It is more usual for dogs than cats to exhibit symptoms of respiratory distress. Tachypnea and conspicuous breathing motions when in a sternal recumbency position are the only indications of respiratory dysfunction in cats, who often mask the severity of their illness. Despite their seeming stability, these patients are often extremely vulnerable and can rapidly decompensate when under stress.

Key Points

• The main objective of managing open fractures is to neutralize further damage to the surrounding tissue while executing prompt, stable osteosynthesis and immobilization.

• Discomfort management should be considered because musculoskeletal diseases can cause severe discomfort.

Degenerative Myopathies

It is a degenerative disease of the musculature. Endocrine imbalances (hyperadrenocorticism, hypothyroidism, and hyperthyroidism), hypokalemia in cats, ischemic myonecrosis in recumbent cattle, post-exercise rhabdomyolysis, chemical agents, poisonous plants, and drug-induced degenerative conditions are some of the possible associations with it.

Key Points

• In diary animals, the health of the mammary gland (udder) is paramount.

• Any udder or teat disease state has a direct impact on milk output.

• Common udder/teet affections include: abscess, mammary gland hematomas, udder cleft dermatitis, udder edema, intramammary hemorrhage, teat damage, ulcerative mammillitis, udder dermatitis, and more.

Introduction

Mammary gland (udder) health is a crucial factor in animals used for production. The state of the udder determines the dairy industry's economics. The output of dairy animals is directly impacted by any udder ailment. Due to selection, breeding, genetic engineering, and animal management, animals under production pressure are more susceptible to a variety of diseases. More safety measures should be implemented in order to shield the udder from illness-causing factors. The many udder and teat affections and their therapeutic management are briefly discussed in this chapter.

Key Points

• Dystocia, uterine prolapse, obstetrics, and torsion of the uterus are among the common obstetrical issues in dairy animals.

• These reproductive abnormalities cause dairy farmers to suffer significant f inancial losses.

Introduction

Every instance of obstetrical complications needs to be handled right away. Along with taking the case history, a general clinical assessment and examination should be performed. Dystocia is one of the various obstetrical problems that is more common in cattle.

Key Points

• In dairy cows, anestrus is a prevalent reproductive condition.

• In dairy farm animals, infertility, pyometra, and repeat breeder cows are the main reproductive syndromes.

Introduction

Farm animals have been raised and chosen specifically for the production of meat and dairy over the years. The livestock business suffers significant f inancial losses as a result of farm animal infertility. If the open span is extended by one estrous cycle as a result of infertility, this explains the 20–25 day loss of output in addition to the expense of treatment, missed work, etc. Farm animals can become infertile for a variety of reasons, including nutritional deficiencies, physiological disorders, and viral infections. These factors can act alone or in concert.

Key Points

• Neurologic dysfunction, which can show up as a wide range of perplexing symptoms and indicators, can accompany gastrointestinal disorders that cause malabsorption and the ensuing nutritional deficits.

• Digestive illnesses are among the most common problems in animals living in tropical countries. They often manifest as intestinal blockage, malabsorption, malnourishment, bleeding in the gastrointestinal tract, diarrhea, and stomach pain or distention.

Introduction

Animal digestive problems can be brought on by a range of conditions, including infections, parasites, and other illnesses. In older dogs and cats, gastrointestinal (GI) disorders of the alimentary tract and hepatobiliary system are prevalent. The majority of the time, GI symptoms in affected animals are caused by inflammatory illnesses; however, degenerative lesions and motility issues can also occur. Acute and chronic conditions are two general classifications for gastrointestinal diseases. Dietary errors, or the worsening of long-term gastrointestinal disorders, are the most frequent causes of acute gastrointestinal disorders. Alongside chronic gastrointestinal disease, colitis or inflammatory bowel disease are frequently diagnosed.

Key Points

• The most frequent physical damage in animals is an aural hematoma;

• Otitis externa is known to result in Zepp's operation, or drainboard from the lateral ear wall.

Introduction

An alternative name for the ear is the sensory organ of hearing. It could display both functional issues and structural abnormalities.

Anatomical abnormalities

Diseases of Pinna

The pinna is affected by several dermatological disorders. In rare cases, a disease only first affects the pinna or the pinna alone. A diagnosis is best determined based on the findings of a comprehensive history, a full physical and dermatologic examination, and the thoughtful selection and assessment of certain diagnostic tests, as with any dermatologic disorder.

The diagnosis of blindness is as follows: an animal that is blind is apprehensive, easily agitated, has an uptight head position with a feeling gait, stumbles forward, steps up high, collides with obstacles in its path, and lacks the cross reflex, photomotor pupillary reflex, and palpebral reflex. Clinical examination of the eye:

• By necked eye

• By magnifying lenses

• By catoptric test: use to detect opacities of the cornea and lens

• By ophthalmoscope

• By tonometry: use to measure intraocular pressure.

Key Points

• Cardiac crises can result in deadly outcomes. Prompt and precise diagnosis leads to early symptom alleviation and increased survival.

• Many illnesses qualify as cardiac crises, including thromboembolic disease, cardiac tamponade, arrhythmogenic disease, and congestive heart failure.

Introduction

A cardiovascular emergency is defined as any condition affecting the heart or vasculature that prevents appropriate blood flow, tissue perfusion, or oxygenation. Cardiac emergencies include a wide range of disorders such as arrhythmias, cardiac tamponade/pericardial effusions, and congestive heart failure (CHF).

Key Points

• There are several causes of abdominal pain.

• It is difficult to diagnose in animals, but behavioral changes may indicate abdominal pain.

• Evaluate and treat abdominal pain promptly to avoid life-threatening situations.

Introduction

Abdominal discomfort is typically acute (onset occurs suddenly), although it can also be persistent. It could be caused by inflammation of the abdominal wall or organs in the abdominal and pelvic cavities. Diagnosis is difficult due to the variety of etiologies involved. Patients with stomach pain demonstrate changes in behavior and posture. Treatment should be based on etiology and the underlying cause.

Key Points

• Shock occurs when the circulatory system fails to provide adequate blood flow to essential organs.

• Oxygen deficiency is a clinical condition caused by insufficient oxygen delivery or tissue incapacity to use oxygen effectively.

• Successful shock management requires early recognition, aggressive monitoring, and appropriate interventions.

Introduction

Shock is a complex physiological syndrome marked by widespread circulatory irregularities that result in inadequate tissue perfusion. In other words, it is a clinical condition caused by an insufficient delivery of oxygen to tissues or the tissues' inability to correctly use oxygen. It is a complication of trauma and diseases typically seen in emergency rooms, such as heart failure, inflammatory conditions (e.g., pancreatitis), and sepsis. In shock, tissue perfusion and oxygen delivery are insufficient to support the tissues' baseline metabolic demands. Whatever the cause, shock is distinguished by reduced blood flow, which is typically accompanied by low blood pressure (hypotension).

Key Points

• Traumatic injuries occur when an animal injures another or falls or strikes surrounding infrastructure (e.g., flooring, fence, gate).

• Common types of injuries include fractures, dislocations, bruises, and wounds, which might be penetrating or not.

Introduction

Physical injuries may occur throughout the export procedure. Slipping and being trampled or mounted during transportation or yarding are likely the most common causes of severe injuries. Poorly built or maintained facilities, such as yards, laneways, fences, gates, and flooring, can increase the risk of injury to animals while they are kept or handled. Poor stockmanship, such as rough handling and putting too much pressure on others, can also increase the chance of harm. Individual animals can be injured by improper restraint or handling, such as dragging an animal by its front or hind legs.

Key Points

• Seizures are common in dogs and cats but uncommon in larger animals.

• Animal seizures can be induced by several circumstances.

• Idiopathic epilepsy is the leading cause of seizures.

• Rapidly rising core body temperature and metabolic alterations lead to fatal outcomes.

Introduction

A seizure is defined as any rapid and uncontrollable movement of the body induced by aberrant neuronal activity in the brain. Seizures are common in dogs and cats, but uncommon in larger animals. Seizures can be severe, affecting the entire body, or moderate, affecting only a section of the body. The pet may or may not be conscious or responsive, and it may urinate.

Seizures are usually brief (1-2 minutes) and self-limiting; however, some animals may experience protracted activity (more than 5 minutes). Seizures that persist longer than 3 to 5 minutes might cause serious complications such as pulmonary or brain edema. Death is caused by a sudden rise in body temperature and metabolic alterations that reach a life-threatening threshold.

Key Points

• Vomiting is a common sign of various conditions, including irritants and toxins, kidney or liver failure, pancreatitis, neurological disorders, and digestive issues. Common in dogs and cats.

• Can be fatal in horses with acute stomach dilatation.

• Ruminants (cattle, buffalo, sheep, and goats) vomit by regurgitating ruminal material through their mouths.

Introduction

Vomiting is the violent ejection of stomach and, on occasion, proximal small intestine contents through the mouth caused by fierce contractions of the diaphragm and abdominal muscles. It is the most prevalent protective disruption in the gastrointestinal system. Vomiting has three distinct phases: nausea, retching, and vomiting. A sense of nausea may or may not cause vomiting. Nausea is scientifically defined as sadness, salivation, lip-licking, and increased swallowing motions in animals. Retching is caused by a series of spasmodic respiratory movements involving the closed glottis. Vomiting is characterized by repeated thoracic invaginations of the abdominal esophagus and cardia. Projectile vomiting often occurs when an animal begins to vomit without going through three stages.

Key Points

• Fluid therapy is crucial for saving dehydrated animals.

• Fluid therapy should be administered within the first 4-6 hours of treatment.

• Ringer lactate is the recommended fluid for diarrhea and enteritis.

• Fluid loss of 4–6 % does not require therapy and does not show any clinical indications.

Introduction

Dehydration is defined as an excessive loss of water and electrolytes from the body (usually due to vomiting and/or diarrhea) or an insufficient intake of water. The body loses water through respiration; however, the skin, face, and/or urine can also cause dehydration. Diarrhea (the loss of fluid and electrolytes from the gastrointestinal tract) is invariably accompanied by dehydration. Chapter 13 provides a brief overview of diarrhea and how it is managed. Dehydration causes lethargy in the patient and, if handled, can have catastrophic consequences for the kidneys and/or other internal organs. Death may occur if the body loses 40% of its water.

Key Points

• Neonatal diarrhea can be lethal without treatment.

• Administer aggressive fluid and electrolyte therapy to address newborn diarrhea.

• Fecal examination and/or culture findings can help control diarrhea.

• Ringer lactate is the preferred fluid.

• There is a high association between animal age and the presence of the causal factor for diarrhea.

Introduction

Diarrhea is one of the symptoms of a variety of medical problems. Diarrhea is characterized by an increased frequency of defecation and stools of varied consistency, which may have an increased concentration of water or a decrease in dry matter content. Increased peristaltic movement causes an increase in caudal flow of ingesta/GIT content, resulting in a decrease in intestinal transit time and thus diarrhea. Diarrhea is lethal in children; therefore, preventing f luid and electrolyte losses prior to diagnosis is critical to saving lives.

Key Points

• Constipation can be caused by a variety of clinical disorders or as a subsequent consequence.

• Rehydration and gentle lubrication of the GIT tract with oral paraffin or linseed oil will alleviate constipation caused by feed and water.

• Small animals, especially cats, are more prone to constipation.

• Common treatments for constipation include dietary changes, enemas, and mechanical removal under anesthesia.

Introduction

Constipation occurs when the ingesta moves slowly or not at all. It is a sign of several intestinal disorders. Although not all extra-gastrointestinal illnesses cause constipation, some do. A systemic illness is characterized by parasympathetic nervous system depression and constipation. Many diseases can lead to constipation as a complication. Chronic constipation in dogs leads to obstipation, which is characterized by drier, firmer, and more compact stools. Dogs cannot defecate and hence require medical intervention, such as surgery or manual feces evacuation. When the colon becomes irreversibly swollen and hypomotile (megacolon), surgery may be necessary. As a result, corrective actions for constipation should be implemented as soon as they are discovered. This will aid in a quick recovery from disease. The current chapter provides an overview of constipation in general and its management.

Key Points

• Drowning is a common cause of accidental death in animals.

• Submersion in water or other fluids prevents atmospheric air from reaching the lungs.

• To diagnose drowning, trustworthy witnesses and a history of drowning at the accident location are required.

Introduction

Drowning or immersion is a type of asphyxial death caused by a body being submerged in water or another fluid medium and preventing atmospheric air from reaching the lungs. Drowning isn't always fatal. When a drowning causes death, it is known as a fatal drowning. Complete submersion is not required for lethal drowning; simply submerging the nose and mouth is sufficient. Drowning is a difficult process. It comprises liquid aspiration, struggle, involuntary movements, dyspnea, and cardiovascular responses. Drowning ultimately leads to hypoxia and death.

Key Points

• Hypothermia occurs when an individual's body temperature drops below its critical level.

• Excessive heat loss or inadequate thermoregulation can lead to this condition.

• It can be minor or severe. Mild hypothermia is harmless, while moderate to severe hypothermia is an emergency.

Key Points

• Physical cooling is more effective in managing hyperthermia.

• Heat stroke occurs when the cause is solely physical.

Introduction

Hyperthermia is an unusually high body temperature (also known as overheating) caused by the body absorbing or producing more heat than it can discharge. Simply said, it is the increase in temperature above the critical point. Heat stroke is most common in animals when they lose control of their body temperature.

Key Points

• Animals can experience varying levels of electric shock. Lightning typically kills animals instantaneously and causes them to fall to the ground without struggle.Most electric shock deaths are caused by cardiac or respiratory arrest.

• Animals often recover from minutes to several hours, rarely going unconscious. Residual nervous system effects, including sadness, paraplegia, and increased cutaneous sensitivity to painless stimuli, can last for days, weeks, or even months.

Introduction

Lightning strikes, broken transmission lines, malfunctioning electrical circuits, or an animal chewing on an electrical cable can all cause an animal to be injured or killed by high-voltage electrical currents. Lightning strikes are seasonal and occur in thunderstorm-prone regions. Caution should always be maintained when investigating probable electrocution situations because the source of the electrification, such as broken transmission wires, may still be present.

Key Points

• Frostbite occurs when exposed to freezing temperatures. Animals that are weak and malnourished are more likely to be injured.

• It is a prevalent condition throughout the winter, particularly in animals who do not have shelter or have inadequate protection to protect them from the cold.

• Excessive cold can harm skin and subcutaneous tissue. In severe circumstances, injuries may be irreversible.

Introduction

Frostbite, also known as freezing cold damage, is caused by prolonged exposure to temperatures below 0º C. Exposure to freezing temperatures causes excessive heat loss, disrupting the body's heat balance and resulting in systemic or local acute freezing injury. Frost bites cause superficial tissue injury, but in extreme cases, gangrene develops in the joint or synovial sheath, and the animal dies from toxemia. However, all animal species are susceptible. It occurs rarely in healthy and well-nourished animals. Animals that have lost their coats or are malnourished are particularly vulnerable to harm. Prolonged exposure to colder temperatures increases the risk of frostbite and the severity of the injury. In the majority of cases, frostbite occurs in animals that are left in winter.

Key Points

• Burns are injuries caused by hot solids or flames.

• Scalds are injuries caused by liquids or steam.

Key Points

• Provide immediate first-aid for wounds.

• For bite wounds, open healing is preferable.

• Silver nanoparticles have antibacterial properties and have been investigated for anticancer applications.

Introduction

Cuts, tears, burns, fractures, and other forms of live tissue injury are all considered wounds. Wounds are typically classified as clean, contaminated, or diseased. Clean wounds are ones that occur in sterile settings, such as surgical incisions. The quantity of germs present distinguishes between contaminated and infected wounds.

Initial Wound Management

The initial step in wound management should be to assess the animal's general stability. Obvious open wounds can divert attention away from more subtle but possibly fatal conditions (such as shock). The general health of the animal influences all areas of care and healing. Some diseases, such as anemia, may impair wound healing by lowering oxygen levels. Malnutrition may also disrupt the healing process. After the initial assessment, the patient should be stable.

Key Points

• Sudden severe bleeding or hemorrhage can cause hemorrhagic shock and death.

• Chronic and or occult bleeding or hemorrhage can cause anemia and even death.

• Common causes of bleeding include trauma, surgical incisions, extreme temperatures, vitamin K deficiency, medicines, and toxins.

Introduction

Bleeding is the extravasation (arterial, venous, or capillary) of blood caused by trauma or a surgical incision.

Key Points

• Animal bites containing poisons, venoms, or diseases cause significant morbidity and mortality.

• Unattended animals are vulnerable to various types of bites, including snakes, spiders, scorpions, bee stings, lizards, and dogs.

• Snake bites can be life-threatening for both humans and animals and require emergency treatment.

• Dog bites can cause rabies in both people and animals.

Introduction

If left alone, curious animals are likely to be bitten by a variety of insects. Bite severity varies by animal species. Typically, stings and bites are painful and dangerous. It can be life-threatening in certain situations.

Key Points

• Allergies are widespread among animals.

• Common allergens include food and drugs.

• Allergic reactions can occur through inhalation, skin contact, or eating.

• Housed cattle develop hypersensitivity pneumonitis, a persistent respiratory illness.

• Chronic exposure to spores in moldy, dusty hay is linked to the disease.

• There are two types of hypersensitivity: acute (also known as anaphylaxis or shock) and delayed.

Key Points

• Patient assessment is only half of the disease diagnosis process.

• Using animal physiological values as a reference point can help measure a patient's health.

• Laboratory results support the patient's evaluation results.

• Patient evaluation findings suggest bodily system involvement.

Introduction

The patient assessment includes the owner's complaint, history, physical examination, and clinical examination of the animals (Fig. 1.1). Proper animal assessment is only part of the illness diagnosis process. Sometimes, evaluation results can be indicative of a medical condition. As a result, at the initial stage, assessing the animal aids in making a confirmation diagnosis. Given its significance, an assessment of the animal must be performed or obtained before concluding the laboratory finding, if available. Assessment can be conducted in several steps, each of which is detailed in the next paragraph. The physiological vital parameters of animals are crucial reference points to conclude the evaluation findings.

? Secondary metabolites of toxigenic fungi on animal food and food ingredients which causes adverse effects when consumed.

? 1942-44: Mycotoxicosis in man and animals was recognized in Russia. Fatal outbreaks of “toxic alimentary aleukia”. 

? 1955: “Hepatitis X” in dog and in cattle and swine in 1957.

? 1960: “Turkey- X disease” and 100,000 turkeys died in England due to Aspergillus flavus infested ground nut meal.

? 1962: Aflatoxin was first isolated.

? Favorable conditions for growth of fungi: Min. 15% moisture (10-13%), relative humidity: 90-95% (> 70%), ambient temp. of 24-25ºC (4-35ºC).

? Moulds infested feed along with nutritionally poor and inadequate diet makes animal more susceptible to mycotoxins induced harmful effects.

? More than 100 toxigenic fungi and mycotoxins have been identified during the last three decades.

? Oxalic acid is an organic dicarboxylic acid that readily forms insoluble salts with cations like calcium & magnesium.

? Sodium, potassium or ammonium salts are highly soluble and can induce toxicity in animals.

Source

? Ingestion of large quantity of oxalate containing plants.

? For toxicity plant should contain > 10% oxalic acid on dry weight basis.

? The form in which oxalate is present in plant mainly as acid oxalate (Oxalis sp., Rumex sp.) or oxalate ions (chenopodiacae).

Nerium oleander

? (Oleander, kaner, rose laurel)

? An ornamental plant and grown in lawns and gardens.

? Other species are Nerium indicum (kaner) & Thevetia peruviana (yellow oleander).

Sources

? Almost all animal species are poisoned.

? Ingestion of branches, stem or leaves during drought or periods of food scarcity or consumption of contaminated water by ruminants or horses.

? Chewing of leaves may be responsible for toxicity in dogs.

? Ingestion of 30-60 gram fresh leaves of oleander is fatal for horses, cattle and sheep.

? All parts of plant are toxic, the leaves and flowers may be less toxic than the seeds.

Source

? Consumption of seeds (dog/cat), Baits containing strychinine kept for foxes, rats, mice

? Cattle are more susceptible to strychnine poisoning parenterally than orally because strychnine is destroyed in the rumen

? Ingestion of birds or rats poisoned with strychnine and ingestion of strychnine treated seeds of peanuts, wheat (in human).

? In Seeds, 1.53- 3.24% total alkaloids out of which 50% is strychnine.

? Loganin (glycoside), Vomicine, α-colubrine, betacolubrine, pseudo strychinine (alkaloid), Brucine, strychnine and strychnicine (leaves), Brucine and small amount of strychnine (bark)

? Average amount of strychnine and brucine in nuxvomica seeds is 1.23 and 1.55% respectively.

? Strychnine- an indole alkaloid found in seeds of Strychnos nuxvomica is extremely stable and can be detected in specimens many years even after the death of animals.

? It is rapidly absorbed from the GIT and parentrally significant amount found in liver and kidney while small amount reaches CNS.

? Metabolized by hepatic MFOs and primarily excreted in urine within 10 hrs.