eChapter Name: Implications on the use of Beta Agonists in Animal Feeding
9789389130515
eBook Name: ANIMAL FEED ADDITIVES
by Nirbhay Kumar and Rashmi Ranjan
Introduction
Growth enhancement technologies have been widely embraced in the livestock industry to improve growth, efficiency and carcass traits. For over 50 years, estrogenic and androgenic hormone implants were widely used in the cattle feeding industry, and it is estimated that approximately 97 percent of feedlot cattle in the U.S. receive one or more implants during the finishing phase (Barham et al., 2003; Tatum, 2006). There is a large body of literature that indicates the positive growth enhancement effects which implants impart on growing and finishing cattle and producers have extensively used implants to increase live body weight, improve average daily gain and feed efficiency, and reduce the number of days cattle are on feed (Apple et al., 1991; Duckett et al., 1997;Milton and Horton, 1996; Perry et al., 1991). Likewise, there is a growing body of literature that indicates the positive response on growth and carcass characteristics that finishing cattle have to beta-adrenergic agonists. The hog industry, and more recently, the cattle feeding industry have increased utilization of beta-adrenergic agonists to improve the efficiency of production. While the use of Ractopamine hydrochloride (Paylean®, Elanco Animal Health, Greenfield, Indiana) has been used extensively in hog production since its approval by the Food and Drug Administration (FDA) in 1999, similar pharmaceutical feed additives have only recently been implemented in commercial cattle feeding operations. Beta-adrenergic agonist use in fed cattle has substantially increased following the FDA approval of Ractopamine hydrochloride (Optaflexx®, Elanco Animal Health, Greenfield, Indiana) in 2003, and the approval of Zilpaterol hydrochloride (Zilmax®, Merck Animal Health, Summit, New Jersey) in 2006. The use of both Ractopamine hydrochloride (RH) and Zilpaterol hydrochloride (ZH) have shown to elicit similar improvements in live weight gain, average daily gain, and feed efficiency as those reported in hormone implants (Allen et al., 2009; Avendano-Reyes et al., 2006; Beckett et al., 2009; Elam et al., 2009; Gruber et al., 2007; Kellermeier et al., 2009; Scramlin et al., 2010). In addition, these compounds have been reported to have profound effects on hot carcass weight, Longissimus muscle area and carcass cutability (Gruber et al., 2007; Hilton et al., 2010; Rathmann et al., 2009; Scramlin et al., 2010; Shook et al., 2009; Vogel et al., 2009). It is because of this that cattle feeders have drastically increased use of beta-agonists since their FDA approval, and a growing portion of the fed cattle population receive a dietary beta-agonist supplement that is provided within the final 20 to 30 days of finishing.