eChapters

Eczema is a troublesome skin condition characterized by redness, cracking, oozing and scaling of the skin. Extremes of heat and cold and even emotional stress seem to play a part in this condition. The patient usually complains of itching and burning in the skin, especially at the night. Sores appear on various parts of the body, but most often on the hands, feet, ears and legs. Eczema may come on at any time of life and in either sex. The commoner manifestations are erythema changing to papule, vesicle, crust, scale and fissure, with serous exudation. In chronic cases, thick scales accumulate.

This is the effect of local irritation by chemical, thermal, actinic or mechanical agents in a hypersensitive individual, subject of an allergy or constitutional disabilities such as gout, chronic nephritis, rheumatism, local sepsis, dyspepsia, alcoholism, uterine disturbances also teething. In some cases heredity may be found.

Papules, vesicles and pustules with some degree of local oedema are found; exudation, crusting and scaling with inflammation of varying severity may be present. These tend to spread to the contiguous areas.

One or both cheeks of an infant or the ear, limbs or trunk are occasionally involved. In adults also similar papulo- vesicular eruptions appear. Sensations of burning, smarting, throbbing or itching are present, according to the acuteness of the process and severity of the inflammation.

Individuals suffering from the more pronounced types of mental disorder are sometimes said to be insane, but the term insanity is a legal one, not a medical term. An insane person is one who cannot distinguish right from wrong or assume responsibilities for his own actions. In the case of a psychotic patient the whole personality is involved. And he is completely out of touch with real world around. Not so the neurotic patient. Only a small part of his personality is involved. Psychotic patients often require hospitalization; neurotic patients rarely do, unless they have some additional physical problem.

Another distinction between these two major groups is that his friends usually bring the psychotic patient to the doctor, while the neurotic comes of his own accord. He knows he is sick, and he usually wants help. Most often he is suffering from a nervous depression.

The term dandruff includes several different conditions of the scalp. There is scaling in which the entire scalp may be covered with loose dry scales. When the hair is combed or brushed, or when the scalp is scratched, these scales fall like snow on the shoulders. Often there is itching, as well, and the scalp may be red from scratching.

What is at first thought to be dandruff may later prove to be some other conditions, such as. seborrhoeic dermatitis, or worse still psoriasis and even neurodermatitis.

Neurodermatitis : It is a chronic type of itching and inflammation of the skin. The itching area may be in some localized spot or it may extend over large areas of the body. The condition may even develop in infants. It may disappear after the age of two and return in the early teens of later. The condition is more often seen in those who suffer from fever, hives and asthma. True cause is not known for most of the people are allergic to many things. Many of them are tense and restless and are troubled with a dry skin. They are hypersensitive and are often given to itching, especially in the bend of elbow or behind the knee. The constant scratching leaves deep scratch marks and causes thickening and furrowing of the skin.

This is the commonest symptom of nearly all respiratory diseases and is indicative of an effort to expel a foreign substance causing irritation on any place in the cough reflex path.

The center is in the medulla close to the respiratory centers. This is activated reflexly by the afferent impulses traveling up mostly along the vagus and to a less extent, the vagus and the phrenic (to bronchi and diaphragm), the spinal accessory, intercostals and other nerves supplying the accessory muscles of respiration. The peripheral fibres of the vagus and the phrenic are also sometimes directly affected causing cough reflex.

The medullary center itself may also be excited or restrained by impulses from superior cerebella centers, so that cough may be induced or controlled by voluntary efforts.

Constipation means difficult or infrequent passage of the feces. In some cases it is due to mechanical obstruction of the intestines, such as cancer, diverticulitis, or perhaps to some functional cause, such as an irritable colon discussed above. In most cases there is no actual obstruction.

Many elderly people suffer from constipation; probably they do not take sufficient fluid. They may think they are drinking enough, but careful observation may reveal that they are having only two or three glasses of liquid a day. For normal bowel habits, one should drink from six to eight glasses of fluid each day.

Sometimes constipation results from ignoring the normal call of nature. Many people suffering from constipation become dependent upon laxatives in early childhood. This is most unfortunate, for it means that the child may be dependent on drugs for the rest of his life. As far as possible do not use an enema on a child unless absolutely necessary. Laxatives and enemas are only for unusual conditions. Nature will provide for the normal needs of the body.

Although the common cold affects all parts of the body, it usually begins in the nose and throat. Colds are so common we hardly give them a second thought, yet they can be rather serious. Most colds are due to virus infections of one type or another. Unfortunately, none of these viruses are susceptible to our present antibiotic medicines. Adenoviruses produce the more serious type of colds, and they are often followed by tonsillitis and sore throat even virus pneumonia, particularly in children. Sometimes the membranes of the eyes are also involved.

The common cold is the most prevalent of all diseases known to man. The average person seems to have two or three colds a year. The condition is highly contagious. When one member of the family has a cold, the others are very likely to have one within a few days.

What makes a person susceptible to a cold? Probably his lowered resistance is a chief factor. Allergic disorders of the nose and throat also make a person more susceptible to colds and other virus infections. Chilling of the body does seem to play a part, particularly in those whose resistance is already weak. Lack of sleep may be another factor.

Any person may carry the cold virus. However, children under six years of age seem readily to pass the infection from one to another, and soon all the family is involved. Colds are always more serious in the younger children.

It may be defined as a chronic condition of the liver in which there is an increase of the connective tissue, a decrease in its size, and a degeneration of the parenchyma.

Alcohol is the most common cause of the cirrhosis of liver. Alcohol reaches the liver through blood stream. Other causes may include improperly prepared foods, poisonous substances, drugs like arsenic, phosphorus, the infectious diseases like syphilis and obstruction of the bile ducts.

Cirrhosis of the liver produced by alcohol abuse is known as portal cirrhosis where as cirrhosis caused by some obstruction such as a stone in the common duct or some narrowing of the bile duct leading from the liver to the small intestine is called as Biliary cirrhosis.

Bronchitis may be defined as a distressing and often serious type of inflammation affecting the windpipe, or bronchial tubes, in the chest. There are two types of bronchitis:

1. Acute Bronchitis
2. Chronic Bronchitis

Acute bronchitis: In acute bronchitis the larynx, trachea and bronchial tubes are acutely inflamed. The tissues are swollen because of irritation; large amount of mucus is secreted and poured into the bronchial tubes to protect the inflamed mucous membrane. Unless this thick, sticky material is removed, it may obstruct the windpipe, causing more severe diseases like atelactasis and pneumonia. The common cold is probably the most frequent cause of acute bronchitis.

During the acute stage of bronchitis there is usually a high fever and some difficulty in breathing. There is a constant cough. Hoarseness may also be present and some pain in the chest. Difficulty in breathing continues until the inflammation has decreased. And thick secretions have removed. Chilliness is present with internal coldness, also cold hands and feet, rawness beneath the sternum, some tightness and oppression of the chest, cough may be dry, hard, ringing, expulsive, paroxysmal, tearing which leaves great soreness under the sternum. After few days the cough, which was at first dry, becomes moist and is accompanied by slight expectoration of mucus and occasionally some blood. As the amount of expectoration increases all the other symptoms decreases, and then in turn abnormal secretion and expectoration also decreases at the end of 7 to 10 days.

By the time a child reaches the age of two he can usually keep himself dry during the day. However, it may be another year or more before he can keep dry all through the night. Even then, the best-trained child may fail to live up to expectations on certain occasions when he is highly excited.

Older boys and girls may also have occasional problems at night, especially when sleeping in a strange bed after a highly exciting evening.

The bladder is emptied unconsciously especially during sleep at night; may be associated with enlarged tonsils, thyroid deficiency, phimosis, intestinal worms, blanitis or vulvitis also sometimes pyelitis, cystitis, oxaluria even minor epilepsy.

There are many causes for this condition, ranging all the way from simple neglect of the calls of nature to degenerative changes in the spinal cord. The condition is found in all classes and at all ages. Nocturnal bedwetting is very common in weak, neurotic children. The next most numerous class is that of women who have born children and who have passed the fiftieth milestone. A laugh, a sneeze, a fright and the urine spurt from the bladder. Probably this is want of proper adjustment of the function of the nervous mechanism of the sphincter and the detrusor and the former fails to inhibit the later.

Partial or complete loss of hair on the scalp is rather common among them. This is more or less to be expected in the female. Premature baldness is a tendency in certain families. Thinning of the hair is often seen in older women, but complete baldness in the female is fortunately rare. Temporary baldness may occur following a fever or some prolonged illness. The hair usually returns after the patient has recovered from the illness.

Sudden loss of the hair in certain areas, a condition called alopecia areata, may sometimes follows extreme nervous shock. This may clear up in a few weeks, although sometimes it will recur. In females excessive hair loss is seen after delivery and during lactation. This is only due to hormonal changes in the body and due to suckling of the milk by the child. This disappears after the child stops weaning. It is not a permanent problem. In children falling of hair occurs due to many reasons such as severe headache, dim eyesight, after a prolonged illness, use of different shampoos and soaps, after a severe head injury and a familial tendency. Generally it is observed that if the parents have thin hair and early loss of hair in their life so is their children.

Many people use various shampoos and creams to prevent hair loss but with no gain. Homoeopathy has a very good treatment for hair loss. Some of the important medicines indicated in the hair loss are given below:

Asthma is a condition of sudden paroxysmal, expiratory, wheezing dyspnoea caused by an abnormal response of the respiratory center to stimulus causing hyperactivity of the vagal endings in the broncho-constricting muscles resulting in bronchial spasm; with it, hyperaemia oftlte mucous membrane followed by excessive bronchial secretion is associated.

This is true spasmodic asthma and in this other conditions of periodic expiratory dyspnoea with a different primary factor should not be included.

The disease has in most a family history and is more common in males; sometimes found in young children but more frequently begins in early adult life. Some of these have definite bronchitis also but in the most, the main is paroxysmal bronchospasm no physical sign obtained in the lungs.

The factors concerned in asthma are (i) bronchospasm from causes central and peripheral, (ii) oedema of the bronchial mucous membrane from allergy. Neuropathic predisposition.

The more immediate causes are (i) allergy, (ii) peripheral stimuli from their site of production, grouped as (a) naso-pharyngeal, (b) alimentary, (c) endocrine (d) broncho-pulmonary (iii) constitutional disturbances.

For ages, man has consumed alcohol to forget his sorrows, to lead him into the realm of happiness. John Keats (1795 -1821), the great romantic English poet, listened to the full-throated music of a nightingale and wanted to become one with that moment of happiness. He thought of taking 'a beaker full of the warm south, of vintage, that has been cooled a long age in the deep delved earth⁷, drinking which he could ' leave the world unseen', and fade away into the dim forest with the singing bird. But Keats was romanticizing the effect of wine on the human mind. A moment later, he decided to give up the idea of taking the assistance of Bacchus and his leopards and switched over to reaching the bird and its music on 'the viewless wings of poesy⁷. This was definitely a wise decision because the alleged euphoric effect on alcohol is a myth. In fact alcohol dulls the brain and retards its activity.

Alcohol is basically a drug. Man consumes it more than any other drug. No form of alcohol, however mild, whether wine or beer or cider, can do good to the human system and health.

It is fallacy to believe that alcohol stimulates the brain. In reality, alcohol depressed the brain. It slows down various centers of control. When alcohol is swallowed, it goes into the stomach where a fraction of the dose enters the blood stream through the blood vessels of the stomach walls. From the stomach, alcohol has to pass into the small intestine. The carbon dioxide in soda water accelerates this flow of alcohol from the stomach into the intestines. This is what makes whisky and soda more dangerous than whisky and water.

Pimples are very common in young people during their teen years. This condition, which is also known as acne, is apparently due to certain hormone changes in the body. It is particularly prevalent during early adolescence, from 12 to 16 years of age, and is more likely to occur in those who have an oily skin. In the early stages a blackhead or comedone blocks the outlet of an oil gland within the skin. This is not a serious problem, for it leaves no permanent effect.

If the sebaceous duct ruptures and the oily material ooze out between the layers of the skin instead of coming to the surface, there may be a cyst or swelling known as a sebaceous cyst. These are somewhat disfiguring, but not harmless unless they become infected and form small abscesses. When these heal they may leave ugly scars. Severe acne may occur on the shoulders, the back and chest, as well as the face and neck.

Effects of diet: Acne is not caused by diet, but certain foods definitely aggravate this condition, especially in some patients. Rich foods, such as chocolate, nuts, cola drinks, ice-cream, fatty meats, and excessive amount of sugar, all seem to aggravate this condition. Certain drugs, such as those containing bromides and iodides, may also play a part in some people.

Some girls develop one to two pimples just before menstruation. These only last a day or two and are of no consequence. But when acne continues over months or years, it is very distressing, especially to a young woman, and something should definitely be done to clear up the condition. Nervous tension due to family trouble may also play a part in continuing this difficult problem. Even in its mildest form, acne usually persists for a year or more until the hormone system of the body has become fully adjusted.

This chapter provides a readily available means of reference for helping in life threatening emergencies, accidents and for providing first aid, where any delay caused by the lack of medication or non-availability of the doctor can have serious consequences either in terms of life or in terms of resulting serious sickness.

As soon as possible competent medical help should be availed of in emergencies and accidents. In the meanwhile the homoeopathic medicines suggested hereafter would provide relief, would halt deterioration in most cases and may save life in many instances.

Emergencies can be life threatening. One of these can be severe haemorrhage, where copious bleeding can lead to death. Obstruction of breathing for different reasons is a matter for concern. Serious accidents are life threatening because there may be unmanageable bleeding, shock and pain.

Below, a list of few medicines and other items required for first aid in emergencies has been given. This can be helpful in homes, in factories and offices.

Homoeopathy system of medicine is the system of healing suited to all the young, and the old, the rich and the poor, the people in the developed as well as the underdeveloped countries and for persons in any place or climate. This is not to take away from the value and utility of the other prevalent systems of medicine. The aim of every science of healing is the relief of sick. Every system is successful in its own fashion. Homoeopathy too fights sickness and does so with remarkable results. Additionally the cost of diagnosis in this system is negligible because the diagnosis is by and large symptomatic. The medicine itself is inexpensive. Notable efficacy and low costs are the strong points of homoeopathic medicine. There are no toxic effects of the drugs, no side effects. The time taken for the medicine to show improvement is not long. Homoeopathic medicines are easy to store and have a long life.

Homoeopathy has been attacked again and again on the ground that the potencised drugs cannot be tested in a laboratory. But that way a number of phenomenon is still outside the pale of conventional science. However, laboratory tests have been going in many countries and certain phenomenon not acceptable to conventional scientific beliefs have been observed.

The homoeopathic system of medicine develops for its special use, the inner medicinal powers of the crude substances by means of a process peculiar to it and which has never been tried, whereby they only all become immeasurably and penetratingly efficacious and remedial. Even those that in the crude state give no evidence of the slightest medicinal power on the human body.

This remarkable change in the qualities of natural bodies develops the latent, hidden powers, which influence the body, change the well-being. This is affected by mechanical action upon their smallest particles by means of rubbing and shaking and through the addition of an indifferent substance, dry or fluid. This process is called dynamization; potencizing and the products are dynamizations or potencies in different degrees.

The homoeopathic materia medica consists of around 1000 drugs, the characteristics of which have been verified or proved. Homoeopathy is unique in that it uses no drug, which has not been proved. The proving has been done by administering pure medicines to healthy human beings and recording in minute detail the effects, mostly adverse, produced by such administration. The tests were conducted on men and women who were mostly medical people and students who were not sick. The drugs were administered in doses consisting of crude drugs or homoeopathic potencies. These volunteers were then asked to describe the effects of the drugs in their own words. These descriptions were noted down by the doctors conducting the experiments and were carefully recorded. Hundreds of thousands of such symptoms were recorded while proving the homoeopathic drugs and the materia medica forms a record of the best proving along with other data collected as a result of laboratory tests and experiments.

In paragraph 25 of the 'Organon of medicine', Dr.Samuel Hahnemann the founder of the system laid down the basis of homoeopathy in the following words: "Now, however, in all careful trials, pure experience, the sole and infallible oracle qi healing art, teaches us that medicine which, in its action on the healthy human body, has demonstrated its power of producing the greatest number of symptoms similar to those observable in the case of disease under treatment, does also, in doses of suitable potency and attenuation, rapidly, radically and permanently remove the totality of the symptoms of this morbid state, that is to say the whole disease present, and change it into health; and that all medicines cure, without exception, those diseases whose symptoms most nearly resemble their own, and leave none of them uncured."

Homoeopathic treatment is based on an overall understanding of the symptoms in the body and mind created by a sickness. Dr. Samuel Hahnemann, the founder of the homoeopathic science of healing, after years of experiment and trial, came to finding that symptom - similarity is the curative method of medically curable diseases. In paragraph 25 of the 'Organon of Medicine⁷, he formulated the principle of 'like cures like' in these words: " Now, however, in all careful trials, pure experience, the sole and infallible oracle of the healing art, teaches us that actually that medicine which, in its action on the healthy human body, has demonstrated its power of producing the greatest number of symptoms similar to those observable in the case of disease under treatment, does also, rapidly, radically and permanently remove the totality of the symptoms of this morbid state, that is to say, the whole disease present, and change it into health; and that all medicines cure, without exception, those diseases whose symptoms most really resemble their own, and leave none of them uncured."

The aforesaid indicates the importance of symptoms in the diagnosis and treatment in homoeopathy. If a drug creates a symptom during the course of proving, then it can be cured by a potencised dose of the drug; whatever may be the name of the disease. For instance, in proving GLONOINE produces a bursting, throbbing sensation in the head in a healthy person. Conversely any surging of the blood to the head requires GLONOINE. This can happen in a sun - stroke, in high blood pressure, in cerebro - spinal meningitis. KALI BICROMICUM produces in proving, a tough, stringy discharge of mucus. In homoeopathy, KALI BICROMICUM cures a similar discharge whether from the nose inwards from mouth, from fauces, from pharynx, from larynx, trachea, bronchi, vagina, and uterus or from any mucus membrane. CACTUSGRANDIFLORUS produces in pure form and gross doses, constriction of the heat and a constriction, anywhere in the body, which is like an iron band being tightened. The same sensation of constriction leads us to the use of CACTUS in a homoeopathic dose and it need not be confined to the heart. There can be constriction of the scalp, in the oesophagus, in the chest, in the abdomen, bladder, uterus, vagina or rectum.

This individualizing examination of a case of disease, for which Dr. Hahnemann give general directions, of which the practitioner will bear in mind only what is applicable for each individual case, demands of the physician nothing but freedom from prejudice and sound senses, attention in observing and fidelity in tracing the picture of the disease.

The patient details the history of his sufferings; those about him tell what they heard him complain of, how he has behaved and what they have noticed in him; the physician sees, hears, and remarks by his other senses what there is of an altered or unusual character about him. He writes down accurately all that the patient and his friends have told him in the very expressions used by them. Keeping silence himself, he allows them to say all they have to say, and refrains from interrupting them (every interruption breaks the train of thought of the narrators, and all they would have said at first does not again occur to them in precisely the same manner after that.) unless they wander off to other matters. The physician advises them at the beginning of the examination to speak slowly, in order that he may take down in writing the important parts of what the speaker says.

He begins a fresh line with every new circumstance mentioned by the patient or his friends, so that the symptoms shall be all ranged separately one below the other. He can thus add to any one that may at first have been related in too vague a manner but subsequently more explicitly explained.

Dr. Samuel Hahnemann laid down the fundamentals of the then new doctrine of homoeopathy in organon of medicine. As observed by him in the 'Introduction⁷ to this work, till then no one had ever taught this homoeopathic mode of cure, no one had carried it out in practice.

Dr. Hahnemann was of the view that the art of the medical practice "should. Rapidly and mildly, effect an unalloyed and permanent cure, and restore to health by means of the smallest doses of a few simple medicines carefully selected according to their proved effect, by the only therapeutic law comfortable to nature, that is Similia Similibus Curentur".

Homoeopathy is based on the following principles:

"The physicians high and only mission is to restore the sick to health, to cure, as it is termed"

The highest ideal of cure is rapid, gentle and permanent restoration of health or removal and annihilation of the disease in its whole extent in the shortest, most reliable and most harmless way on easily comprehensible principles.

Unprejudiced observer of a sick person takes note of nothing in every individuars disease except the changes in the health of the body and of the mind, which can be perceived externally by means of the senses. "All these perceptible signs represent the disease in its whole extent, that is, together they form the true and only conceivable portrait of the disease"

The homoeopathic system of medicine is one of the finest systems of cure available in the world. It achieves in totality the ideal laid down by its founder, Dr. Samuel Hahnemann:

"The highest ideal of cure is rapid, gentle and permanent restoration of the health, or removal and annihilation oftlie disease in its whole extent, in the shortest, most reliable, and most harmless way, on easily compreltensible principles".

In homoeopathy, not a single drug is used without knowing its effect on healthy human beings. Hence there is no shooting in the dark. The system operates, by and large, without laboratory tests and other expensive means of diagnosis, which are being used when not needed and that too, unfortunately on patients who can hardly afford the expenses.

Cost wise, there is no medical system in tlie world, which is as inexpensive as homoeopathy. No patient who requires a speedy cure without side effects can ignore homoeopathy; no doctor who has nothing but the good of his patient at heart can overlook the utility and effectiveness of homoeopathy and no Government which has to balance its budget can afford not to use homoeopathy in hospitals and other institutions run for the health and care of the sick and thus it is the most cost effective treatment

The discovery of homoeopathic system of medicine makes a fascinating story.

18.1 Introduction

The commercially available water quality simulation models with various dimensions (1D, 2D and 3D) and database software designed to quantify movement and concentration of contaminants in lakes, streams, estuaries, and marine environments. The following water quality models were described below (Table 18.1).

18.2 Environmental Fluid Dynamics Code

The Environmental Fluid Dynamics Code (EFDC) is a multifunctional surface water modeling system, which includes hydrodynamic, sediment-contaminant, and eutrophication components. It has been applied to over 100 water bodies including rivers, lakes, reservoirs, wetlands, estuaries, and coastal ocean regions in support of environmental assessment and management and regulatory requirements. IT is a state-of-the-art hydrodynamic model that can be used to simulate aquatic systems in one, two, and three dimensions. It has evolved over the past two decades to become one of the most widely used and technically defensible hydrodynamic models in the world. It uses stretched or sigma vertical coordinates and Cartesian or curvilinear, orthogonal horizontal coordinates to represent the physical characteristics of a waterbody. It solves three-dimensional, vertically hydrostatic, free surface, turbulent averaged equations of motion for a variable-density fluid. Dynamically-coupled transport equations for turbulent kinetic energy, turbulent length scale, salinity and temperature are also solved. The model allows for drying and wetting in shallow areas by a mass conservation scheme.

17.1. Introduction

Throughout human history, the coastal plains and Lowland River valleys have usually been the most populated areas over the world (Wolanski et al., 2004). At present, about 60% of the world’s population live along the estuaries and the coast (Lindeboom, 2002). This is degrading estuarine and coastal waters through pollution, eutrophication, increased turbidity, overfishing and habitat destruction. The pollutant supply does not just include nutrients; it also includes mud from eroded soil, heavy metals, radionuclides, hydrocarbons, and a number of chemicals including new synthetic products.

The impact on estuaries is commonly still ignored when dams and irrigation farming are proposed on rivers. In addition, estuaries are often regarded as sites for future development and expansion, and have been increasingly canalized and dyked for flood protection, and their wetlands infilled for residential areas.

All these factors impact on the biodiversity and productivity and hence, the overall health of estuaries and the ecosystem services they provide to humans. They increasingly lead humans away from the possibility of ecologically sustainable development of the coastal zone. Integrated coastal zone management plans are drawn up worldwide but, in the presence of significant river input, most are bound to fail because they commonly deal only with local, coastal issues, and do not consider the whole river catchment as the fundamental planning unit. It is as if the land, the river, the estuary, and the sea were not part of the same system. When dealing with estuaries and coastal waters, in most countries land-use managers, water-resources managers, and coastal and fisheries managers do not cooperate effectively due to administrative, economic and political constraints, and the absence of a forum where their ideas and approaches are shared and discussed (Wolanski et al., 2004). 

16.1 Introduction

Littoral drift is a geological process by which sediments such as sand or other materials, move along a beach shore.Long Shore Drift is the movement of eroded material, in a zig zag way, along the coast. The process arises when waves approach the shore obliquely. That is to say, at an angle other than 90°. The effect of this is determined by factors such as the direction and fetch of the present wind and, in the long term, of the prevailing wind.

Waves striking the shore at an angle as opposed to straight on will cause the wave swash to move up the beach at an angle. The swash moves the sediment particles up the beach at this angle, while the backwash brings them, solely under the influence of gravity, directly down the beach. Some geologists consider a beach to be merely a shoreline feature of deposited material, but William Bascom (1980) has argued that a beach is the entire system of sand set in motion by waves to a depth of ten meters or more off ocean coasts. Submerged, longshore bars are therefore also part of the beach, and thus beaches can be viewed as either:

15.1 Introduction

A tsunami is a series of waves created when a body of water, such as an ocean, is rapidly displaced. Earthquakes, mass movements above or below water, volcanic eruptions and other underwater explosions, landslides, large meteorite impacts and testing with nuclear weapons at sea all have the potential to generate a tsunami. The effects of a tsunami can range from unnoticeable to devastating. The term tsunami comes from the Japanese words meaning harbor (“tsu”,) and wave (“nami”,). The term is created by fishermen who returned to port to find the area surrounding their harbor devastated, although they had not been aware of any wave in the open water. Tsunamis are common throughout Japanese history; approximately 195 events in Japan have been recorded.

A tsunami has a much smaller amplitude offshore, and a very long wavelength (often hundreds of kilometers long), which is why they generally pass unnoticed at sea, forming only a passing “hump” in the ocean (Fig. 15.1). Tsunami have been historically referred to as tidal waves because as they approach land, they take on the characteristics of a violent onrushing tide rather than the sort of cresting waves that are formed by wind action upon the ocean (Iwan, W.D., 2006).

14.1 Introduction

An oil spill (or slick) is the intentional or unintentional release of oil into the natural environment as a result of human activity. The term often refers to marine oil spills where oil is released into the ocean or coastal waters (Fig. 14.1).

Oil can refer to many different materials, including crude oil, refined petroleum products or by-products, oily refuse, oil mixed in waste, or oily ballast. Oil is also released into the environment from natural geologic seeps on the seafloor, as along the coastline. The fate, behavior, and environmental effects of spilled oil can vary depending upon the type and amount of material spilled. In general, lighter refined petroleum products such as diesel and gasoline are more likely to mix in the water column and are more toxic to marine life, but tend to evaporate relatively quickly and do not persist long in the environment. Heavier crude or fuel oil, while of less immediate toxicity, can remain on the water surface or stranded on the shoreline for much longer. Oil from the Exxon Valdez and Gulf War oil spills, while weathering over time, has persisted along the shoreline for years after the spill.

13.1 Introduction

Eutrophication, means an increase in chemical nutrients — typically compounds containing nitrogen and phosphorus in an ecosystem. It may occur on land or in water. The term is however often used to mean the resultant increase in the ecosystem’s primary productivity (Fig. 13.1), in other words excessive plant growth and decay and even further impacts, including lack of oxygen and severe reductions in water quality and in fish and other animal populations.

12.1 Introduction-Nitrogen

Nitrogen is a chemical element which has the symbol N and atomic number 7. Elemental nitrogen is a colourless, odourless, tasteless and mostly inert diatomic gas at standard conditions, constituting 78.1% by volume of Earth’s atmosphere. Nitrogen is a constituent element of all living tissues and amino acids. Many industrial important compounds, such as ammonia, nitric acid, and cyanides are made up of nitrogen.

12.1.1 History

Nitrogen (Latin nitrogenium, where nitrum (from Greek nitron) means “native soda”and genes means “forming”) is formally considered to have been discovered by Daniel Rutherford in 1772, who called it noxious air or fixed air. That there is a fraction of air that did not support combustion is well known to the late 18th century.

Argon was discovered when it is noticed that nitrogen from air is not identical to nitrogen from chemical reactions. Compounds of nitrogen were known in the Middle Ages. The alchemists knew nitric acid as aqua fortis (strong water). The mixture of nitric and hydrochloric acids is known as aqua regia (royal water), celebrated for its ability to dissolve gold (the king of metals). The earliest industrial and agricultural applications of nitrogen compounds involved uses in the form of saltpeter (sodium- or potassium nitrate), notably in gunpowder, and much later, as fertilizer, and later still, as a chemical feedstock.

11.1 Introduction

Salinity is the saltiness or dissolved salt content of a body of water. The technical term for saltiness in the ocean is halinity, from the fact that halides, chloride specifically are the most abundant anions in the mix of dissolved elements. In oceanography, it has been traditional to express halinity not as percent, but as parts per thousand (ppt ), which is approximately grams of salt per liter of solution. In other disciplines chemical analyses of solutions, and thus salinity is frequently reported in mg/L or ppm (parts per million). Prior to 1978, salinity or halinity was expressed as % usually based on the electrical conductivity ratio of the sample to “Copenhagen water”, an artificial sea water manufactured to serve as a world “standard”(Lewis, E.L 1980). In 1978, oceanographers redefined salinity in Practical Salinity Units (psu): the conductivity ratio of a sea water sample to a standard KCl solution (UNESCO, 1981a) (UNESCO, 1981b). Ratios have no units, so it is not the case that 35 psu exactly equals 35 grams of salt per litre of solution (UNESCO, 1985).

These seemingly esoteric approaches to measuring and reporting salt concentrations may appear to obscure their practical use; but it must be remembered that salinity is the sum weight of many different elements within a given volume of water. It has always been the case that to get a precise salinity as a concentration and convert this to an amount of substance required knowing much more about the sample and the measurement than just the weight of the solids upon evaporation. For example, volume is influenced by water temperature; and the composition of the salts is not a constant. Saline waters from inland seas can have a composition that differs from that of the ocean. For the latter reason, these waters are termed saline as differentiated from ocean waters, where the term haline applies.

10.1 Introduction

Biochemical Oxygen Demand (BOD) is a chemical procedure for determining how fast biological organisms use up oxygen in a body of water. It is usually performed over a 5 day period at 20 C. It is used in water quality management and assessment, ecology and environmental science. BOD is not an accurate quantitative test, although it could be considered as an indication of the quality of a water source.

10.2 Typical BOD values

Most pristine rivers will have a 5-day BOD of less than 1 mg/l. Moderately polluted rivers may have a BOD value in the range of 2 to 8 mg/l. Municipal sewage that is efficiently treated by a three stage process would have a value of about 20 mg/l. Untreated sewage varies, but averages around 600 mg/l in India and as low as 200 mg/l in the U.S., or where there is severe groundwater or surface water infiltration. Slurry from dairy farms is around 8000 mg/l and silage liquor around 60000 mg/l.

9.1. Introduction

Oceans (from Okeanos in Greek) are saline waters that cover almost three quarters (71%) of the surface of the Earth. The area of the oceans is 361 million sq. km., and nearly half of the world’s marine waters are over 3,000 meters deep.

Though somewhat arbitrarily divided into several “separate” oceans, these oceans are in fact one global, interconnected body of salt water, often called the World Ocean. The major divisions are defined in part by the continents and a variety of archipelagos, and are labeled the Pacific Ocean, the Atlantic Ocean, the Indian Ocean, the Southern Ocean, and the Arctic Ocean. Smaller regions of the oceans are called seas, gulfs and straits.

There are a some smaller bodies of salt water that are not interconnected with the World Ocean. These are not considered to be oceans or parts of oceans, though some of them have been given the name, sea.

Geologically, an ocean is an area of oceanic crust covered by water. Oceanic crust is the thin layer of solidified volcanic basalt that covers the Earth’s mantle where there are no continents. From this point of view, there are three “oceans” today: the World Ocean, and the Black and Caspian Seas that were formed by the collision of Cimmeria with Laurasia. The Mediterranean Sea is very nearly its own “ocean”, being connected to the World Ocean through the Strait of Gibraltar, and indeed several times over the last few million years movement of the African Continent has closed the strait off entirely, making the Mediterranean a fourth “ocean”.

8.1 Introduction

A lake is a body of water or other liquid of considerable size surrounded entirely by land (Fig. 8.1). A vast majority of lakes on Earth are fresh water, and most lie in the Northern Hemisphere at higher latitudes. In ecology, the environment of a lake is referred to as lacustrine.

Fig 8.1 A Typical Lakes

Large lakes are occasionally referred to as “inland seas” and small seas are occasionally referred to as lakes. Smaller lakes tend to put the word “lake” after the name, as in Green Lake, while larger lakes often invert the word order, as in Lake Ontario, at least in North America. The term lake is also used to describe a feature such as Lake Dal, which is a wet basin most of the time but may become filled under seasonal conditions of heavy rainfall and snowfall. Many lakes are artificial and are constructed for hydro electric power supply, recreational purposes, industrial use, agricultural use, or domestic water supply.

7.1 Introduction

The coast is one of the most important boundaries in the world. It separates the marine part of the world from the continents. It separates the salt-water communities from fresh water communities; it separates land life from water borne life but amphibians living both environments (Fig. 7.1).

Some of the marine organisms move towards estuary for reproduction with less water salinity. The coastline as such is not a stable. It fluctuates in place over considerable distances due to erosion and sedimentation, but also due to the relative change of sea level with respect to land. The coastal zone is thus a very mobile part of the earth from a geographical point of view. Due to its specific geophysical properties, the coast is also a very important area for the development of flora and fauna. There is hardly any other part of the world that houses such a variety of species, both in flora and fauna.

The abundance of opportunities along the coast has also attracted a lot of human activities. The coastal zone has become an indispensable resource for mankind. It provides excellent opportunities for fisheries, housing, recreation, transport, defense purpose, industrial activities and many others. The influx of man with their social and economic activities, their needs for safe housing, food, drinking water, and with the tremendous quantities of waste they are producing poses at the same time a serious threat to the unique features of the coastal zone. It is therefore necessary to study this valuable region so as to prevent that competing activities are gradually causing depletion of the resources in the coastline. The following figures (Fig. 7.1and 7.2) show the typical coastal area of rocky coast and sandy coast.

6.1. Introduction

A river is a large natural waterway. The source of a river may be a lake, a spring, or a collection of small streams, known as headwaters. From their source, all rivers flow downhill, typically terminating in the ocean. The mouth, or lower end, of a river is known as its base level.

A river water is confined to a channel, made up of a stream bed between banks. Most rainfall on land passes through a river on its way to the ocean. Smaller side streams that join a river are tributaries. The scientific term for any flowing natural waterway is a stream; so in technical language, the term river is just a shorthand way to refer to a large stream. Rivers throughout history have been the source and support for civilization, and many major cities today are near a river of some sort (Fig. 6.1).

6.1.1 Topography

A river conducts water by constantly flowing from a higher to a lower elevation, thereby converting the potential energy of the water into kinetic energy. It starts to form loops and snakes through the plain by eroding the river banks. Sometimes the river will cut off a loop, shortening the channel and forming an oxbow lake from the cut off section. Rivers that carry large amounts of sediment may develop conspicuous deltas at their mouths, if conditions permit. Rivers, whose mouths are in saline tidal waters, may form estuaries. River mouths may also be rias.

5.1 Introduction

The water quality modeling methodologies are started from conceptual models such as defining the problem in a particular region of interest like fresh water ecosystem, coastal ecosystems, ocean ecosystems, the following methodology can be studied carefully for water quality modeling.

Identification of problems in the region of interest

Monitoring of field data using standard methods like APHA, USGS, BIS etc.

Evaluation of primary data for the toxins, higher amount of concentration from the ambient conditions

Processing of primary data to secondary data

Based on the primary data and secondary data, suitable modeling software can be used. If the temperature of the region is higher than the ambient, it should be used Qual2E, MIKE21 etc.

Modeling results can be compared with field data for calibration and validation.

4.1 Introduction

The developed or commercially available models can be applied for any water bodies such as fresh water lakes, ponds, rivers, estuaries and marine ecosystems. The predicted results can be compared with proved with field data and existing approved models and applies to the other such ecosystems. In this chapter, we can discuss about modeling of water bodies, water quality model, spatial discretizafion, modeling pollutants and toxicants, concentration modeling, hydrodynamic mixing zone analysis.

4.2 Modeling of Water bodies

The need for predictive water quality modeling has arisen largely as a result of increased eutrophication of lakes throughout the world (Forsberg, 1987; Canfield and Hoyer, 1988). The most common modelling approach is exemplified by the development and application of steady state, input-output models. Generally, nutrient concentrations are calculated from net inputs and chlorophyll a concentration is predicted by correlation with the limiting nutrient, most often phosphorus (Dillon and Rigler, 1975; Canfield and Bachmann, 1981; OECD, 1982).

Factors that can also influence phytoplankton biomass, such as light, climate, biological interactions and internal loading of nutrients, are not considered. Further more, the assumption that a lake is a continuously mixed system is very restrictive and only applicable at discrete times of the year. As a result, the shortcomings of such approaches include an inability to make predictions in the face of varying physical and biological conditions, and a failure to offer insights into the determinants of changing water quality.

3.1 Introduction

By the end of the twentieth century one of our most important scientific accomplishments has been the explicit realization that the human population is changing the earth system. Some of these changes are occurring at a remarkable rate. We know, with certainty, that human activities are changing land use, habitats, the chemistry of the Earth’s atmosphere and water, rates and balance of biogeochemical processes, and diversity of life on the planet (Vitousek et al. 1997). One prominent mode of human disturbance has resulted from activities that mobilize the nutrient elements nitrogen and phosphorus through land clearing, production and applications of fertilizer, discharge of human waste, animal production, and combustion of fossil fuels (Nixon 1995).

As a result of these activities, surface waters and ground waters throughout the world now have elevated concentrations of N and P compared to concentrations even in the middle of the 20th century. Our mobilization of N and P has accelerated the fluxes of these elements to coastal waters, and fertilization of coastal ecosystems is now a serious environmental problem because it stimulates plant growth and disrupts the balance between the production and metabolism of organic matter in the coastal zone. Coastal eutrophication is a recently recognized phenomenon (Nixon 1995), and scientific investigation of this human disturbance has progressed for only a few decades, so our conceptual model of the problem is evolving rapidly. Here, I describe 2 phases in the evolution of our conceptual model of how nutrient enrichment disrupts coastal ecosystems, and then finish with a view to the future, suggesting critical questions that must be answered as we work to advance and broaden our understanding of this complex environmental problem. This examination of conceptual models is designed as a complement to the excellent general reviews of coastal eutrophication (Vollenweider 1992, Heip 1995, Nixon 1995, Jørgensen & Richardson 1996, National Research Council 2000).

2.1 Historical Development

We have seen in Chapter 1 that modeling is about establishing cause effect relationship. Perhaps one of the earliest attempts in this direction is made as early as 1848 in Germany where it was tried to establish a relation between purity and pollution to the occurrence of certain biological organism. But as far as water quality modeling is concerned the first major breakthrough in this direction is the effort of Streetor and Phelps (1925) in oxygen sag curve. They developed model for estimating DO and BOD in Ohio River. The work of O’Conner (1962) for bacteria models are major milestone in pre-computer era modeling.

With the advent of computer during 1960s complicated kinetics and time variable simulation came into being. Most of the workers presented their efforts in terms of linear programming based water management models concerning waste discharge. Thomann(1963) has formulated linear programming based models for dissolved oxygen in an estuary. So a stage is set for study of eutrophication through modeling, but the problem is determination of values of various parameters in these equations.

During 1970s models expanded in terms of complexities mainly because of enhanced computational facilities. Two dimensional and dynamic framework has started replacing one dimensional steady state configurations. In the same year, Di Toro presented an analysis of the steady state two dimensional concentration distribution that results in the horizontal plane from the continuous discharge of a non-conservative substances (DO and BOD) into an infinite body of water.

A model is something that mimics the behavior of some real system of interest. Our interest here will be in water quality models, which are usually equations, and which predict some result based on factors that influence that result. A water quality model is a representation of a real system. The essence of a good water quality model is that it is simple in design and exhibits the basic properties of the real system that we are attempting to understand. The model should be testable against empirical data. The comparisons of the model to the real system should ideally lead to improved mathematical models. The model may suggest improved experiments to highlight a particular aspect of the problem, which in turn may improve the collection of data. Thus, modeling itself is an evolutionary process, which continues toward learning more about certain processes rather than finding an absolute reality.

Water pollution is a large set of adverse effects upon water bodies such as lakes, rivers, oceans, groundwater caused by human activities. Although natural phenomena such as volcanoes, storms, earthquakes etc. also cause major changes in water quality and the ecological status of water while these are not deemed to be pollution. Water pollution has many causes and characteristics. Increases in nutrient loading may lead to eutrophication. Organic wastes such as domestic sewage and farm waste impose high oxygen demands on the receiving water leading to oxygen depletion with potentially severe impacts on the whole ecosystem. Industrial discharge a variety of pollutants in their wastewater including heavy metals, organic toxins, oils, nutrients, and solids. Discharges can also have thermal effects, especially those from thermal and nuclear power stations, and these too reduce the available oxygen. Siltbearing runoff from many activities including construction sites, forestry and farms can inhibit the penetration of sunlight through the water column restricting photosynthesis and causing blanketing of the lake or river bed which in turns damages the ecosystems the process is called as eutrophication.

Pollutants in water include a wide spectrum of chemicals, pathogens, and physical chemistry or sensory changes. Many of the chemical substances are toxic or even carcinogenic. Pathogens can obviously produce waterborne diseases in either human or animal hosts. Alteration of water’s physical chemistry include acidity, conductivity, temperature, and excessive nutrient loading. Even many of the municipal water supplies in developing countries can present health risks leads to many diseases.

Molecular diagnostics has witnessed groundbreaking technological advances in recent times, starting from automated sample preparation to real time amplification technology. Possibility to develop and run assays for ever increasing number of clinical queries has become effortless due to the technological advances. However, the state of the art in quality assurance and quality control practices for molecular diagnostics has seldom been up to the expectations if one considers accuracy for once in a lifetime genetic tests or new genetic test targets appearing almost every single day. In the face of such issues, clinical laboratories are struggling to develop appropriate quality assurance programs for the molecular diagnostic tests they conduct. In addition, legislation and government policies threaten to increase oversight of genetic tests to a level not seen before in laboratory medicine, for example, FDA’s guidance on in vitro diagnostic multivariate index assays (IVDMIA).

To relate patient results to previous test results or to absolute values in clinical practice guidelines, those results need to be comparable across time and methods. This may either be achieved by designing the identical value across methods and test versions or by using reliable and stable conversions. Therefore, the establishment of international standards and reference materials is of paramount importance. Monitoring molecular test system outputs and statistical analysis might provide a good way to obtain such standards; however, such traditional QC (Quality Control) strategies can be slow to take root in molecular diagnostics.This chapter highlights general and specific issues relevant for quality assurance and quality control in the routine molecular diagnostics laboratory and guidelines for designing quality manuals for a molecular diagnostic laboratory.

12.1 Assays for molecular diagnosis of Acute Myeloid Leukaemia (AML)

Acute Myeloid Leukaemia (AML), also known as Acute Myelogenous Leukaemia or Acute Myeloblastic Leukaemia or Acute Granulocytic Leukaemia or Acute non Lymphocytic Leukaemia is an aggressive type of cancer which affects blood and bone marrow. AML is a heterogeneous disorder if one considers its clinical status, therapeutic responses and overall prognosis.¹ This disease called acute because it progresses very fast and myeloid as it originates from myeloid cell line in the bone marrow.

In bone marrow blood cells are made in a controlled way. When AML occurs excess numbers of immature leukaemia cells are produced. Overproduction of leukaemia cells in bone marrow disables bone marrow to make mature white blood cells. These accumulated immature cells are unable to function properly (Inability to fight infection).

Diagnosis: Correct diagnosis is important for a successive treatment for AML. There are several tests available to diagnose AML but not all tests will be used for each person. The following tests may be used to diagnose AML.

11.1 Principle

In situ hybridization techniques involve detection of specific nucleic acid sequences to in morphologically preserved chromosomes, cells or tissue sections. Along with immunocytochemistry, in situ hybridization can correlate microscopic topological information to gene activity at the level of DNA, mRNA or protein. The FISH protocol involves 1) denaturation and hybridisation performed on Day 1 and 2) washing and detection performed on Day 2. DNA of the chromosomes and the probes are denatured and allowed to hybridize overnight on the first day. On day 2, slides are washed to remove unbound DNA sequences followed by detection, counterstaining and mounting of the slides.