eChapters

In the world of academic publishing, Article Processing Charges (APCs) have emerged as a significant barrier, particularly for researchers from countries with limited resources like India. These charges, often levied by open-access journals to cover the costs of peer review, editing, and dissemination, have created a financial divide that impedes equitable access to scholarly communication. This chapter delves into the multifaceted challenges posed by APCs and outlines potential solutions to address the inequities they perpetuate (Fig. 6.1).
6.1. The Burden of Article Processing Charges
The financial burden of APCs is disproportionately felt by researchers in developing nations. Many prestigious open-access journals charge APCs ranging from $1,000 to $5,000 or more per article. For researchers in high-income countries, these charges might be manageable, supported by robust institutional funding or grants. However, for their counterparts in countries like India, where research funding is limited and often tied to modest institutional budgets, such costs are prohibitive. The disparity in income and currency exchange rates further amplifies this challenge. A charge of $2,000, for instance, could equate to several months’ salary for a researcher in India, compared to a fraction of that amount for a researcher in the United States or Europe.

In the evolving landscape of agricultural sciences, integrative research models have emerged as a cornerstone for addressing complex, multifaceted challenges. These models bridge the gap between theoretical frameworks and their practical applications, ensuring that innovations are not just conceptual but also actionable and impactful. This chapter delves into the essence of integrative research models, highlighting their significance, successful case studies, and strategies to foster their adoption and effectiveness in agricultural progress.
8.1. The Need for Integrative Research Models
Agriculture today is at the nexus of critical global challenges, including climate change, food security, biodiversity loss, and resource scarcity. Traditional, siloed research approaches often fall short in addressing these interconnected issues. Integrative research models offer a paradigm shift by combining insights from diverse disciplines such as agronomy, ecology, economics, data science, and social sciences. This approach not only enhances the depth of understanding but also ensures that solutions are holistic and sustainable (Fig. 8.1).
One of the primary drivers for adopting integrative research models is the increasing complexity of agricultural systems. Modern agriculture is no longer

Global agricultural research, an essential field in ensuring food security and sustainable development, is heavily influenced by the academic and publishing ecosystems in Europe and North America. This chapter examines the challenges faced by researchers from developing regions, focusing on limited representation in editorial boards, barriers to accessing high-impact journals, and the overarching dominance of Western institutions (Fig. 9.1).
These issues underscore the need for greater inclusivity and recognition of regional expertise to foster a more equitable global research landscape.
9.1. Dominance of Europe and North America in Agricultural Research
Publishing
The dominance of Europe and North America in agricultural research publishing is evident from the distribution of international journals in agriculture and allied disciplines. Approximately 75% of these journals originate from these regions. Breaking this down further:
• Europe accounts for 43.6% of international journals, with leading contributors including the United Kingdom (14.1%), the Netherlands (8.5%), Germany (6.2%), France (4.3%), Italy (3.5%), and other European countries (7.0%).
• North America contributes 31.4%, with the United States alone publishing 28.5% and Canada accounting for 2.9%.

The credibility of academic publishing hinges significantly on the integrity of journal rating systems. These systems, designed to evaluate and rank academic journals based on various metrics, play a pivotal role in shaping research priorities, funding allocations, and academic career trajectories. However, despite their importance, many journal rating systems are criticized for lacking transparency and ethical rigor (Fig. 10.1).
This chapter explores these shortcomings, focusing on potential biases embedded in current systems and proposing solutions to enhance their transparency and fairness.
10.1. Role of Journal Rating Systems in Academic Publishing
Journal rating systems serve as gatekeepers in the academic publishing ecosystem. They influence where researchers choose to publish their work, how institutions evaluate scholarly output, and how funding agencies allocate resources. Metrics such as impact factor, h-index, and SCImago Journal Rank (SJR) are commonly used to rank journals. These metrics, while useful, often reduce the multifaceted nature of scholarly impact into single numerical values, potentially oversimplifying and distorting the evaluation process. The reliance on these metrics creates a feedback loop wherein highly ranked journals attract more submissions, increasing their citation counts and reinforcing their dominance. This system can marginalize smaller or niche journals that publish

Predatory journals undermine the integrity of academic publishing by charging exorbitant fees without providing rigorous peer review. These deceptive entities exploit the academic community, especially targeting early-career researchers, those from underfunded institutions, and scholars in developing countries. By prioritizing profit over quality, predatory journals erode trust in the research ecosystem, dilute scientific knowledge, and tarnish the reputation of genuine academic endeavors (Fig. 11.1).
This chapter delves into the multifaceted challenges posed by predatory journals and outlines comprehensive strategies for researchers, institutions, and policymakers to combat their pernicious effects.
11.1. Understanding Predatory Journals
Predatory journals are characterized by their lack of transparency, absence of editorial rigor, and aggressive solicitation of authors. They often masquerade as legitimate open-access journals but fail to adhere to the ethical standards of scholarly publishing. Unlike reputable journals, which uphold rigorous peer-review processes to ensure the validity and originality of research, predatory journals accept articles with minimal or no scrutiny. This results in the dissemination of low-quality or even fraudulent research, undermining the credibility of academic literature.
Several red flags can help researchers identify predatory journals. These include:

National journals play a crucial role in the dissemination of regionally relevant research, particularly in specialized fields such as agricultural sciences. These journals act as accessible platforms for researchers, practitioners, and policymakers to share findings, innovations, and solutions tailored to local contexts. Strengthening national journals is essential for fostering knowledge exchange, promoting inclusivity in scientific communication, and addressing the unique challenges faced by different regions (Fig. 12.1).
This chapter explores strategies for improving the quality, visibility, and credibility of national journals, with examples from countries across the globe, including those outside North America and Europe. Case studies of successful initiatives are included to illustrate best practices for empowering local publishing platforms, with a particular focus on non-English publications.
12.1. The Importance of National Journals in Agricultural Sciences
Agricultural sciences are inherently context-dependent. Local factors such as climate, soil type, cropping systems, and socioeconomic conditions influence the challenges faced by farmers and the solutions that are most effective. National journals provide a vital medium for addressing these region-specific issues, enabling researchers to publish studies that may not align with the broader focus of international journals. Furthermore, these journals often cater to the immediate needs of local policymakers, extension workers, and educators, ensuring that research findings are translated into actionable outcomes.

The final chapter of this exploration into agricultural sciences casts a forward-looking lens on the opportunities and challenges that lie ahead. As global population levels continue to rise, with estimates suggesting we will surpass 9 billion people by 2050, the demand for sustainable and efficient agricultural practices has never been more urgent. Emerging challenges, such as climate change, biodiversity loss, soil degradation, and water scarcity, coupled with rapid technological advancements, are reshaping the landscape of agricultural research and publishing (Fig. 16.1).
This chapter delves into how the integration of advanced technologies, the promotion of open-access publishing, and global cooperation can revolutionize agricultural sciences. It also highlights the importance of equity, innovation, and adequate funding in driving this transformation.
16.1. Advanced Technologies and Their Transformative Potential
In the past decade, advanced technologies like artificial intelligence (AI), machine learning (ML), and big data analytics have become central to scientific inquiry. These tools are now increasingly being applied to agricultural research, offering unprecedented opportunities for innovation. For example, AI-powered predictive models can help forecast crop yields, pest outbreaks, and weather

The One Nation One Subscription (ONOS) scheme is a cornerstone of India’s ambition to become a self reliant and developed nation by 2047 envisaged by Hon’ble Prime Minister Shri Narendra Modi Ji. The initiative is a significant step to enhance access to scientific and academic resources across the country. This initiative can positively impact Indian journal ratings and boost subscriptions by addressing several challenges listed below:
• Increased Access to Global Resources
• Enhanced Research Quality 118 | Promoting Excellence in Agricultural Sciences
• Support for Smaller Institutions
• Boost to Indian Journals
• Fostering Interdisciplinary Collaboration
By bridging gaps in resource accessibility and improving research output, ONOS can play a pivotal role in elevating the status of Indian journals on global platforms. While evaluating Indian Journals of Agricultural and Allied Sciences, comprehensive and inclusive databases with many characteristics listed below should be adopted so as to ensure equal focus and benefit from international exposure:
• The database should have regional and multi-lingual journals with proper translation or abstracting, interdisciplinary research output, more and new journals/technical reports/official scientific documents/conference proceedings etc, open access for smaller journals to ensure readily accessible cutting-edge research in agriculture
• The database should provide more nuanced metrics that value realistic impact and localized research contributions considering immediate practical applications
• The database should include a wide range of journals across diverse disciplines, including agriculture, forestry, veterinary sciences, and environmental science with more inclusion of regional and specialized journals, providing access to a broader spectrum of agricultural research
• The database should emphasis on journals from developing regions, which often publish research addressing local agricultural challenges. This diversity helps in showcasing research contributions from regions/countries with significant agricultural economies
• The database of agriculture-related journals should overlap with other related fields viz., environmental science, biology, and social sciences, reflecting the interdisciplinary nature of agriculture. This helps researchers access a more comprehensive set of resources
• The database have detailed subject areas, allowing researchers to pinpoint agricultural science journals within relevant subfields like:

Quantitative genetics is the study of continuous or quantitative traits and their underlying mechanisms. The main principals of quantitative genetics developed in the 20th century was largely in response to the rediscovery of Mendelian genetics. Mendelian genetics in 1900 centered attention on the inheritance of discrete characters, e.g., smooth vs. wrinkled peas, purple vs. white flowers. This focus was in stark contrast to the branch of genetic analysis by Sir Francis Galton in the 1870’s and 1880’s who focused on characteristics that were continuously variable and thus, not clearly separable into discrete classes. A contentious debate ensued between Mendelians and Biometricians regarding whether discrete characteristics have the same hereditary and evolutionary properties as continuously varying characteristics. I The Mendelians (led by William Bateson) believed that variation in discrete characters drove evolution through mutations with large effects I The Biometricians (led by Karl Pearson and W.F.R. Weldon) viewed evolution to be the result of natural selection acting on continuously distributed characteristics. This eventually led to a fusion of genetics and Charles Darwin’s theory of evolution by natural selection: main principals of quantitative genetics, developed independently by Ronald Fisher (1918) and Sewall Wright (1921), arguable the two most prominent evolutionary biologists.
Interestingly, Galton’s methodological approaches to continuously distributed traits marked the founding of the Biometrical school, which is what many consider to be the birth of modern statistics. Karl Pearson was inspired greatly by Galton, and he went on to develop a number of methods for the analysis of quantitative traits. We will talk more about Galton and Pearson later on in this course. One of the central goals of quantitative genetics is the quantification of the correspondence between phenotypic and genotypic values. It is well accepted that variation in quantitative traits can be attributable to many, possibly interacting, genes whose expression may be sensitive to the environment

The amount of variation is measured and expressed as the variance. When values are expressed as deviations from the population mean the variance is simple the mean of the squared values. For example, the genotypic variance is the variance of genotypic values and the environmental variance is the variance of environmental deviations. The total variance is the phenotypic variance of the variance of phenotypic values, and is the sum of the separate components.
Components of Variance
The components of variance and the values whose variance they measure are listed as follows:
The total variance is the phenotypic variance, or the variance of phenotypic values, and is the sum of the separate components. Thus
But if genotypic values and environmental deviations are correlated, VP will be increased by twice the covariance of G with E because if P = G + E, VP = V (G + E) = VG + VE + 2 CovGE. d. The term 2 CovGE is zero when G and E are uncorrelated. Also when there is an interaction between genotypes and environments, there will be an additional component of variance due to the interaction i.e.

Definition of Animal Breeding
Animal breeding, as the application of science to the genetic improvement of animals, implies a close inter relationship between theory and its application. Genetics has provided the matrix form which logical principles could be developed and tested by experimentation and practice.
During the 20th century, genetics has assumed a broader meaning and numerous subdivisions of the discipline has emerged. Advances in animal breeding also have drawn heavily on contributions from statistics, biochemistry, physiology, economics and other disciplines. Animal breeding and reproductive physiology have been uniquely interwoven.
Animals with superior genotypes cannot contribute to succeeding generations unless their reproductive capacity is maintained at satisfactory levels.
Livestock production is an economic enterprise. Hence, animal breeding recommendations must withstand the scrutiny of economic, as well as genetic considerations, before they are accepted and integrated into enterprises by breeders. As a consequence, a close relationship between the breeder and the science, application and theory has been nurtured.
History of Animal Breeding
• Till 500 A.D. when the fall of Roman Empire began animal breeding was at its esteem. Withthe fall of Roman Empire for about 1000 years called Dark and Middle Ages, animal husbandry was at a still.
• From 1700 A.D., again there was an improvement. The beginning of modern animal breeding is to be found mainly in England and Europe.
• The British Royalty encouraged horse breeding especially for race horses. The Earls and Dukes imported bulls from Holland and bred their native stocks. Dutch cattle were introduced into Hereford shire that laid the foundation of the present Hereford cattle. By crossing the native and Dutch cattle and subsequent inbreeding, the British cattle were improved far beyond the best.

Weaning to 210 days: Weight in kg of feed consumed for producing one kg of live weight for the period from weaning to 210 days of age.
10 Mortality percentages (as percentage)
Pre-weaning mortality: No. of piglets died during the period birth to weaning (28/56 days) the number of piglets born alive.
Post weaning mortality: Number of piglets died during the period from 28/56th to 365 day to the total number of piglets available at weaning.
Adult mortality: Number of adult pigs died to the number started at one year (in percentage).
List of registers to be maintained:
• Birth register
• Youngstock register
• Adult stock register
• Disposal register
• Mortality register
• Weighment register
• Farrowing and growth record
• Service register
• Boar performance register
• Sow performance register
• Veterinary register
• Feed efficiency register
• Account register

Natural Selection
In nature, the main force responsible for selection is of interest because of its apparent effectiveness and because of principles involved. Some of the most interesting cases of natural selection are those involving man himself. All races of man that now exist belong to the same species, because the races are interfile or have been in all instances where mating have been made between them. All races of man now in existence had a common origin and at one time probably all man had the some kind of skim pigmentation – which kind we have no sure way of knowing. As the number of generations of man increased, mutations occurred in the genes affecting pigmentation of the skin causing genetic variations in this trait over a range from light to dark or black.
Natural selection is a very complicated process and many factors determine the proportion of individuals that will reproduce. Among these factors are differences in mortality of the individuals in the population especially early in life, differences in the duration of the period of sexual activity and in the degree of sexual activity itself and the differences in the degree of fertility of individuals in the population. They are also examples of adaptive evolution.

Tandem Selection
Selection is practiced for one trait at a time until satisfactory improvement has been achieved in this trait. Then, selection efforts for this trait are relaxed and efforts are directed towards the improvement of a second, then for a third and so on, until finally each trait has been improved to the desired level. This method is the least efficient of all the three methods, from the stand point of the amount of genetic progress made for the time and effort by the breeder. Efficiency of tandem selection depends a great deal upon the genetic correlation between the traits selected for. If the genetic correlation is positive and desirable, improvement in one trait by selection would automatically result in improvement in the other trait not selected for, and then the method could be quite efficient. Otherwise, if there were little or no genetic correlation between the traits, which means that they are inherited independently, the efficiency would be less. When the two traits are negatively correlated, improvement in one trait is nullified or neutralized by the regression in the other. For example, in poultry, selection for egg number will result in reduction in egg weight, as they are negatively correlated.
Independent Culling Level (ICL) Method
Method of selecting two or more traits but they both need to meet a minimum standard. It is very strict that if the animal didn’t meet one trait it would be rejected. Independent Culling level (ICL) Method selects several characteristics or traits simultaneously.
Breeders set minimum or maximum culling levels or standards or criteria for each trait of selection objectives. Any animal not meeting all criteria is not selected for use in the breeding program regardless of the level of excellence of other traits. With each successive generation of progeny, the minimum quality of each characteristic is raised thus ensuring improvement of these traits. For example, a breeder has a view of the minimum requirements for milk yield, fat yield, and service period for which cows are breeding. The breeder will determine what the minimum acceptable quality for each of these traits will be for progeny to be folded back into her breeding program. Any animal that fails to meet the quality threshold for any one of these criteria is culled from the breeding program. Thereby, it causes the loss of excellent genes from the population for a particular trait.

Combining Ability Estimation
Crosses made in a definite fashion are a prerequisite for combining ability estimation. Estimated by half-sib (GCA) and full-sib (SCA) mating. Various steps like parent selection for crosses, performing crosses, their evaluation, and interpretation are involved while estimating of combining ability. For analysis of crosses, biometrical techniques like diallel analysis, partial diallel, and Line x tester analysis are used. If GCA variance is higher than SCA variance the importance of AGA & parent selection will be effective for the improvement of such traits. If SCA variance is higher than GCA variance there is importance of NAGA( dominance & epistasis) & Heterosis breeding may be rewarding. If GCA=SCA variance then AGA & NAGA are equally important in the expression of character, In this situation reciprocal recurrent selection may be adopted for population improvement.
Selection for GCA
General combining ability (GCA) is the average value of the inbred line based on its behavior in crosses with other lines. The mean performance of the line is expressed as deviation from the mean of all crosses.GCA is owing to the activity of genes which are largely additive in their effects as well as additive × additive interactions.

There is urgent need to increase the production in order to meet the demand for the exploding population. This could be achieved by applying various modern methodologies in selection and breeding of livestock. Increasing the productivity through genetic improvement requires adequate identification and intensive selection of genetically superior sires. About 93 per cent of the total herd improvement comes from breeding of young bulls from tested sires and only six per cent from selection of dams.
With the advances in artificial insemination and cryopreservation of semen, a sire has a potential of serving 3/4th million cows and producing 1/4th million progenies.
Thus, selection of bulls is of great importance in dairy herd improvement.
For maximising the genetic gain by sire selection, it is essential that the method of estimating breeding values of sires should be unbiased and efficient. The breeding value refers to the average genetic effect of the genes passed on by the individual to its offspring and is estimated to know whether the individual is genetically superior to other individuals or not for the trait concerned.

As we look to the future, climate crisis is looming large and it is essential to address several aspects of climate-resilient agriculture. One of the critical areas that require attention is scaling up climate-resilient agricultural practices. This involves promoting and supporting the adoption of climate-resilient agricultural practices, such as conservation agriculture, agroforestry, and climate-smart agriculture, among small-scale farmers and rural communities. There is vast scope for upgrading traditional technologies making best use of modern technologies. To achieve this, there is a need:
• To increase funding and investment in climate-resilient agriculture. This can be achieved through a combination of government funding, private sector investment, and international aid. The funding should be used to support research and development, technology transfer, and capacity building, as well as to provide financial incentives to farmers to adopt climate-resilient agricultural practices.
• Strengthening international cooperation is also critical for promoting climate-resilient agriculture. This involves sharing knowledge, expertise, and resources among countries, as well as collaborating on research and development, technology transfer, and capacity building. International cooperation can also help to promote policy and institutional reforms that support climate-resilient agriculture.
• Promoting climate information and early warning systems. This involves providing farmers and rural communities with accurate and reliable climate information, as well as early warning systems that can help them prepare for and respond to climate-related disasters. Climate information and early warning systems can be provided through a range of channels, including mobile phones, radio, and television.
• Supporting climate-resilient agricultural research and development is also critical for promoting climate-resilient agriculture. This involves investing in research and development that focuses on improving crop varieties and animal breeds, developing new technologies and practices, and improving our understanding of the impacts of climate change on agriculture. Research and development can also help to identify and promote climate-resilient agricultural practices that are suitable for different regions and contexts.
• Promoting policy and institutional reforms is also essential for supporting climate-resilient agriculture. This involves promoting policies and

Both possess a pronounced thyme-like odor and flavor. And, both are employed in culinary preparations. The oil of the two plants is closely related in chemical composition. The oil can be obtained by steam distillation of the herb. The dried leaves and flowering tops derived from S.hortensis constitute winter Savory of commerce. The best quality of savory comprises of dried leaves only. S.hortensis constitutes summer Savory. Savory is an erect pubescent annual herb, 20-30 cm in height with pinkish branches, fund in Kashmir State of India. Leaves are oblong – linear or lanceolate with deep-pitted glands on both sides. Flowers are small auxiliary cymes. It grows in Southern France, Germany, Spain, and other parts of Europe, also in England, Canada and the USA. The dried leaves are brownish-green in color, up to 10 mm in length. The odor is strong, warm and highly aromatic; the taste is somewhat sharp and camphoraceous. It is marketed both in whole and ground form. Satureia hortensis Linn., the summer Savory or Garden type, is largely cultivated, although it also grows wild, to some extent. An annual, it is less developed than Satureia montana. Its stalks are herbaceous, covered with soft and linear leaves. The branches frequently are reddish in color. Flowers of the Garden Sage are whitish, dotted with red, growing in a bouquet from the summit of the branches. Satureia montana Linn., the winter Savory, as the French call it “Poivre Diane” grows wild on sunny and calcareous and hill-side of Southern France, especially in the Alpes-Maritimes. It is a hardy, shrub-like perennial, attaining a height of 8-14 inches with small, yellowish or slightly purple leaves, growing

Long Pepper or Pipli is the dried fruit of Piper longum, which is a slender, aromatic climber with perennial woody roots, occurring in the hotter parts of India, from the Central Himalayas to Assam, Khasi, and Mikir hills and Lower Hills of Bengal, and evergreen forests of the Western Ghats from Konkan to Travancore in Kerala State, India; it has also been recorded from Nicobar Islands. The plant has creeping jointed stems; young shoots are downy; leaves are 5-9 cm long, 3.5 mm wide, ovate, cordate, with broad rounded lobes at the base; female spikes are cylindrical, pedunculate, male spikes are larger and slender; female spikes are 1.3-2.5 cm long and 4.5 mm in diameter; fruits are ovoid; yellowish orange, minute, droop and are sunk in fleshy spike. The female spikes are sharper, sessile and blunt at the tips and erect, are red when ripe; flowers are numerous and packed. Indian Long Pepper is mostly derived from the wild plants, the main sources of supply being Assam State in India, followed by West Bengal, Nepal and Uttar Pradesh. Small quantities are also available from evergreen forests of Kerala State, West Bengal and certain parts of Andhra Pradesh. It is reported to be cultivated at lower elevations in the Annamalai hills in Tamil Nadu, India, and in parts of Assam, in particular, the heaviest (in India) rainfall region, Cherrapunji. It is cultivated in Meghalaya also; India produced about 200 tonnes in 1990-91. The Long pepper, as sold in India, appears to be derived from 2 or 3 species, including one which is Indonesian. Indian Long Pepper is a product of either Piper longum or Piper peepuloides, while the Indonesian or Java Long Pepper imported from Malayasia is from Piper retrofractum. The fruits of these species are used for the same purpose, though they do vary in their comparative effectiveness.

Combination of an opioid (butorphanol/buprenorphine) and an alpha-2 agonist (xylazine/dexmedetomidine) along with an NMDA antagonist and benzodiazepine (tiletamine-zolazepam or ketamine-midazolam) will make up a balanced anaesthetic cocktail. Examples for balanced anaesthetic cocktails are xylazine/dexmedetomidine-butorphanol-midazolam-ketamine and butorphanol/ buprenorphine-tiletamine zolazepam-dexmedetomidine/xylazine (Ko, 2013; Cagle et al., 2017; Sooryadas et al., 2019; Verma et al., 2020). The latter ones are costly due to the tiletamine-zolazepam and dexmedetomidine in them, while the former ones are cost effective alternatives.
Xylazine/Dexmedetomidine-Butorphanol-Midazolam-Ketamine (XBMK/DBMK) Anaesthetic Cocktail
The preparation can be made by drawing 0.1 ml/kg of ketamine (50 mg/ml presentation) along with 0.1 to 0.2 ml/kg of the xylazine-butorphanol-midazolam (XBM) or dexmedetomidine-butorphanol-midazolam (DBM) sedative cocktail in a single syringe. For intravenous administration, 0.1 ml/kg each of ketamine and the sedative cocktail is to be chosen, while for intramuscular administration 0.1 ml/kg of ketamine and 0.2 ml/kg of the sedative cocktail is preferred. The volume of the cocktail that needs to be administered intramuscularly will be larger by 0.1 ml/kg when compared to the tiletamine-zolazepam based anaesthetic cocktails. Anticholinergic premedication is preferred prior to administration of anaesthetic cocktail containing xylazine (Nesgash et al., 2016), particularly if given intravenously. The XBMK/DBMK anaesthetic cocktails will induce anaesthesia in a few minutes, which last for 20 to 40 minutes (Ko, 2013; Verma et al., 2019; Verma et al., 2020). Intravenous administration of the anaesthetic cocktail provides shorter duration of surgical plane of anaesthesia. When administered as said above, the combination provides xylazine @ 0.2 - 0.4 mg/kg or dexmedetomidine @ 2.5 - 5 mcg/kg, butorphanol @ 0.1 - 0.2 mg/kg, midazolam @ 0.125 - 0.25 mg/kg and ketamine @ 5 mg/kg body weight which is as per their recommended doses when given in combination (Verma et al., 2019; Verma et al., 2020).

Total Intravenous Anaesthesia
Maintenance of anaesthesia, conventionally, is done either with inhalants, or as intermittent boli of injectable anaesthetics. The pharmacological complexity of the uptake and elimination of inhalant anaesthetic agents, and the need of technical and functional knowhow, of inhalant anaesthesia machine, either restricts its use in majority clinical practice, or is not used in an ideal manner. Injectable anaesthetic drugs as intermittent boli “as and when needed” is the practice by majority practitioners for maintenance of anaesthesia. Intermittent bolus injections of anaesthetic drugs creates intermittent peaks of anaesthesia and thereby increased side effects due to high doses. Instead, a continuous rate infusion of the anaesthetic drugs, in smaller quantities is employed in TIVA, providing balanced anaesthetic maintenance. These drugs act through different pathways, providing analgesia, muscle relaxation and unconsciousness, in a synergistic manner. TIVA is thus a technique in which anaesthesia is maintained solely through the use of intravenous drugs, without reliance on inhaled anaesthetics (Kennedy, 2016). Total intravenous anaesthesia is commonly achieved using a combination of sedative-hypnotics, analgesics and even muscle relaxation drugs, often administered via continuous rate infusion (CRI) to maintain stable drug levels (Verma et al., 2020). The key advantage of TIVA is that it provide stable haemodynamics because it maintains the sympathetic tone well. Also, this procedure promises less environmental contamination avoiding exposure to anaesthetic gas in the operating rooms. TIVA is emerging as a popular option in a range of surgical procedures due to its benefits in patient comfort, recovery, and control over anaesthesia depth. Few examples of anaesthetic cocktails for total intravenous anaesthesia in dogs through constant rate infusion are mentioned below. Easy understanding on how to calculate and prepare CRI is mentioned later.
1. Dexmedetomidine (2 mcg/kg/hr), midazolam (3 mcg/kg/min), lignocaine (50 mcg/kg/min) and ketamine (40 mcg/kg/min) as a cocktail intravenous infusion in normal saline. Anaesthesia is induced by intramuscular administration of a cocktail of DBMK mentioned in earlier chapter, followed by an intravenous loading dose of lignocaine at the rate of 2 mg/kg prior to the cocktail intravenous infusion (Verma et al., 2020).
2. Xylazine (1 mg/kg/hr), midazolam (3 mcg/kg/min), lignocaine (50 mcg/kg/ min) and ketamine (40 mcg/kg/min) as a cocktail intravenous infusion in

Introduction 
SDG 3 emphasizes good health and well-being for people globally. In this chapter, we will focuses on the health and well-being of the Indigenous Khasi Tribe living in Meghalaya, India. The Khasi Tribe comprises 7 sub-tribes, commonly known as ‘Seven Huts’ or ‘HynniewTrep, HyniewSkum’ in the Khasi language. The 7 sub tribes are Khynriam, Pnar, Bhoi, War, Maram, Lyngngam and Dikko. Although the culture, tradition, and beliefs are shared among all subtribes, earning them the common name Khasi Tribe, there are slight differences in terms of topography. Some sub-tribes live in sloping or steep mountainous areas, engaging primarily in forestry and horticulture, while others reside in plain areas, where they cultivate agricultural crops. As an indigenous group, the Khasi community follows certain beliefs and practices related to health and well-being. The Khasi tribe is a matrilineal society where women hold great responsibility at home and in the community. Some researchers have acknowledged that the Khasi tribe is one of the tribes in India with a better status in terms of literacy rates and nutritional status. (D Agrahar- Murugkar, 2004). Approximately 83% of the Khasi tribe are agrarian. The main food items that boost their immune system and make them strong and healthy include rice, dal, potato, tomato, bamboo shoot, pumpkin, green vegetables, citrus fruits, and meat (beef, pork, fish, eggs, and dry fish), which they cook in their own indigenous style. The majority of them are non-vegetarian. A common stimulant is betel nut, which has been used since ancient times as a social mediator to connect with others and form friendships. The Khasi people are hardworking; enjoy games and sports, and traditional music. In terms of social well-being, the Khasi tribe has a strong sense of “we feeling”, supporting one another, following ethical and moral instincts, and respecting one another. They believe in the spirits of Mother Nature (ki blei, ki basa). To maintain strong bonding and enhance Khasi Tribe sentiments, various festivals are celebrated every year, such as Shad Suk Mynsiem, Shad Nongkrem, Seng Kut Snem, Pom Blang, and Beh Diengkhlam. They also pay homage to freedom fighters who have died for the Khasi land, such as Tirot Sing, Kiang Nongbah, and Phan Nonglait. Following the legacy of these freedom fighters, various leaders are heading civil groups that monitor the performance of government administration and other welfare states for common social well-being.

Introduction 
NEP was announced by Sri Narendra Modi, the PM of India on July 29,2020. The system was introduced after the debates by experts from various fields. The earlier education system was 10+2+3 which changed to 5+3+3+4.The NEP 2020 have less curriculum contents and increases learning, reasoning and logical skills. After the completion of UG courses in the higher education they may opt for the Research Methodology. The 5+3+3+4 design is equivalent to the age groups 3-8 years, the foundational stage which is mainly based on play or activity based learning, 8-11 years, the preparatory stage which is based on play, discovery, activity based and interactive classroom learning, 11-14 years, the middle stage is based on experiential learning in Science, Mathematics, Arts, Social Science and Humanities and 15-18 years, the secondary stage emphasized on multidisciplinary study, greater critical thinking, flexibility, student choice of subjects. Government will constitute a Gender Composition plan to provide equal and standard education to all girls and third gender learners. 10th and 12th standard students are no longer to sit for board exams which will be accessible to test core competencies rather than memorised facts with all students allowed to take the exam twice. Internships will be started from 6th standard. The teaching upto 5th standard will be in regional languages and mother tongue. The assessment covers reforms with 360 degrees overall progress report tracking the progress for achieving learning outcomes. Within 2030, the B.Ed degree duration will be 4 years. The holistic U.G education will be having several exit options and certification will be provided.

    Temperature variations in crop canopies can be affected by number of factors including water availability. When soil water is low, canopy temperature can rise rapidly, even upto 10°C warmer than the air temperature. Irrigation can help reduce canopy temperature, but it may not be able to keep below the threshold for heat damage. Canopy management and row orientation can affect the air temperature within a canopy. Potassium fertilization can reduce canopy temperature variation which can increase seed yield. Temperature affects many plant processes including photosynthesis, transpiration, respiration and flowering. The rate of photosynthesis increases with increase in temperature, up to a certain limit. High Photosynthetic rates do not necessarily support high rates of dry matter accumulation may be due to increased respiration. If temperature profiles are measured in crop canopies, normally, it is expected that the temperature may decrease with increase in height and is minimum at the crop canopy in a well irrigated crop during day time. It is mainly due to increase in water vapor content within the crop stand due to soil evaporation. During night time, the temperature decreases with increase in height and temperature of the crop canopy will be more as no transpiration takes place during night time.
4.1. Instability
Atmospheric instability occurs when the earth’s atmosphere is unstable, which leads to highly variable weather patterns. In an unstable atmosphere, there will be rapid changes in temperature, pressure and wind with height (Fig.4.1). The instability is caused by the rising of warm air. Atmospheric instability can lead to the development of thunderstorms, tornadoes and convective clouds. The factors that determine the atmospheric instability are as follows:
4.1.1. Temperature Lapse Rate: Lapse rate is the rate at which the air temperature
changes with altitude. If the air temperature lapse rate is greater than the adiabatic lapse rate, the atmosphere is unstable. The rate at which temperature of an air parcel changes with increase in height without loosing or gaining heat from the surrounding environment is called adiabatic lapse rate. In case of adiabatic process, there will be no exchange of heat between the air parcel and surrounding environment when the air parcel moves vertically upwards.
4.1.2. Humidity: The humidity in the air parcel determines whether it cools at
dry or wet adiabatic lapse rate. Therefore, greater the humidity of the air, unstable conditions will increase. When the dry air mass raises vertically upwards, the rate of decrease in temperature with increase in height is called dry adiabatic lapse rate. The rate at which the moisture air mass gets cooled with increase in height is called wet adiabatic lapse rate.

Microclimate under irrigated conditions and dryland conditions can differ significantly due to variations in water availability, which influences several environmental parameters such as temperature, humidity, soil moisture, and vegetation cover. The crops are grown both under irrigated and dryland / rainfed situations. The major difference between irrigated and dryland conditions is availability of water. In irrigated areas, the crops are regularly provided with water through irrigation at regular intervals. Under dryland situations, the water availability to the crops depends upon the rainfall and/or stored soil moisture. Under irrigated situations, there are two different possibilities as indicated below:
• vast stretch of irrigated areas
• isolated pockets of irrigated areas in predominantly dry areas. In dryland areas the following possibilities exist:
• humid and moist sub-humid areas where predominantly rice based cropping systems are adopted during rainy season
• per-humid areas where plantation crops and rice grown during rainy season.
• dry sub-humid areas with rice based cropping systems in low lands and finger millet, maize based cropping systems in upland areas
• semi-arid regions where kharif crops are grown during rainy season.
• rabi-crops grown under conserved moisture conditions during post rainy season.
• arid regions where pearl millet based cropping system are practiced during rainy season.
• hill agriculture
The microclimatic conditions are likely to vary between irrigated and rainfed conditions due to different agro-ecological settings. The comparative analyses of microclimatic variation under both conditions are given below:

A farm microclimate refers to the specific climatic conditions of a small, localized area within a farm. These conditions can differ significantly from the broader regional climate due to various natural and man-made factors. Understanding and managing microclimates is crucial for optimizing crop growth, animal welfare, and overall farm productivity. Modern commercial dairy production requires a special approach to the microclimate on the farm. High quality milk and animal health depend on the conditions of their keeping. At the same time, farm for dairy production for the most part do not have the means to control and manage the microclimate, in contrast to poultry farm. When organizing the correct process of controlling the microclimate, a prerequisite is the presence of an automated system for collecting data. Generally animals adapt to a wide range of weather conditions although their growth and productivity varies with weather conditions. Buffaloes and cows form the main component in dairy industry. The extent to which these animals can adapt to different weather conditions is given below: Successful management of buffalo rearing will be incomplete without wellplanned and adequate housing facilities (Fig.10.1).
Improper planning in the arrangement of animal housing may result in management problems, increase in disease incidence, additional labour charges and hence decrease in the profit of the farmer. During erection of a house for dairy buffaloes, care should be taken to provide comfortable accommodation for individual animals. It is important to ensure:
• Proper sanitation
• Durability
• Abundant supply of clean water
• Arrangements for the production of clean milk under convenient and
economic conditions.
Buffaloes may be successfully housed under a wide variety of conditions, ranging from close confinement to little restrictions except at milking time. However, two types of farms are in general use.

The weather plays a very significant role in crop production. The agricultural production depends upon four factors i.e., soil, genetic material, management practices and weather. Of these four factors, the farmers have least control on weather and have to evolve management strategies to cope up with the weather conditions. The crops can be grown only when the seasonal weather conditions are conducive to crop production. The different weather factors on crop growth and development are as follows:
13.1. Temperature
For each species of plants, there are upper and lower limits of temperature beyond which the growth is negligible. The optimum temperatures at which growth is maximum may vary from crop to crop but will be within the range of 15 to 30°C. Temperatures beyond 45°C cause wilting of plants. There are also optimum temperature requirements during different stages of crop growth.
13.1.1. Warm Season Crops: The Warm season crops are rice, sorghum, maize,
pearl millet, groundnut, pigeon pea, cowpea etc. These crops are also called tropical crops. These crops can be grown during monsoon season and in early summer season. The optimum temperatures for these crops fall in the range of 15°C to 38°C.
13.1.2. Cool Season Crops: The crops which grow best under cool weather
conditions are called cool season crops and are generally grown during winter season. The important cool season crops are wheat, mustard, Chickpea, barley, potato, Safflower. These crops are also called temperate crops. The optimum temperature for better growth of these plants range from 10°C to 30°C.
13.2. Effect of Temperature on Growth and Development
The crop development is described in terms of its various stages of growth including germination of seeds, emergence of seedlings, tillering, flower initiation, grain formation, physiological maturity and harvest maturity etc., before it completes its life cycle. The various stages of growth, the crop passes through are called phenophases. Phenology is the study of timing of the phenophases. The temperature and day length (photo period) will have considerable influence on phenology of the crops. The temperature from which crop development begins is called base temperature. The base temperature is considered as 8°C for the crops grown during kharif season and 5°C for the crops grown during winter

There is growing demand for increasing fruit production as fruits are considered to be healthy, nutritious and easy to digest. Fruits are natural foods and have export potential as well as provide opportunities for increasing employment by establishing fruit processing industries. Some of the fruits can be grown around the year where as some fruits are of seasonal in nature. Usually, the fruit cultivation is undertaken by establishing orchards. In case of orchards, wrong decisions in planting may result in huge loss and therefore right method of planting is the key factor for establishing orchards.
The fruit crops are of three types depending on the adoptability to the climate of the region and are grouped as
• tropical fruits
• sub-tropical fruits
• temperate fruits
The microclimate of the orchards depends upon
• height of the plants/trees
• horizontal spread
• canopy architecture
• spacing/plant density
• age of plantation
• seasonal weather
15.1. Tropical Fruits
The tropical fruits require higher temperature throughout the year. The crops do not require low temperature for breaking dormancy and for flowering. The plants are ever green and grow throughout the year. There plants are well adopted to regions where the minimum temperatures are more than 10°C and very sensitive to frost. There are grown in tropical regions between 23°N to 23°S latitudes. The optimum maximum temperature for growth and development ranges from 30 to 37°C.
15.2. Sub-Tropical Fruits
The sub-tropical fruits perform better between temperate and tropical climates as the plant requires both high and low temperatures. Some of the fruit crops are green and some of those are deciduous. The temperate fruit crops are very sensitive to frost. The sub-tropical fruit plants break dormancy of flower buds

1. Introduction:- Overview of Good Laboratory Practices (GLP)
1.1 Definition and Scope of GLP
GLP refers to a set of standards that govern the organizational processes, personnel responsibilities, and conditions under which laboratory studies are conducted. It aims to regulate research environments and ensure the generation of high-quality, traceable, and reproducible results. The scope of GLP encompasses a wide range of scientific fields including pharmaceuticals, agrochemicals, veterinary products, and environmental safety assessments. Good Laboratory Practices (GLP) regulations were developed by the Organization for Economic Co-operation and Development (OECD) and well adopted by regulatory agencies world-wide. The primary objective of GLP is to promote high standards of accuracy and integrity in non-clinical research to protect human health and the environment.
1.2 Principles of GLP
The fundamental principles of GLP include:
• Study Planning and Protocol Development: Every study must have a clear plan and defined objectives, which should be outlined in a comprehensive protocol.
• Personnel Responsibilities: The roles of study directors, scientists, quality assurance personnel, and support staff are clearly defined.
• Test Systems and Facilities: Laboratories must maintain appropriate facilities and control systems for conducting studies. These include properly calibrated equipment, controlled environments, and standardized procedures.
• Data Integrity and Reporting: Data must be meticulously recorded, verified, and archived, ensuring it is traceable and reproducible.
• Study Documentation and Archiving: All records, raw data, and reports must be stored and accessible for a period defined by regulations, ensuring transparency and reproducibility.

Introduction
Antimicrobial resistance (AMR) represents one of the most significant public health challenges of modern times. The discovery of antibiotics in the early 20th century revolutionized medicine, transforming once-fatal infections into manageable conditions and enabling life-saving procedures such as organ transplantation, chemotherapy, and joint replacement surgery. However, the overuse and misuse of antibiotics in human medicine, veterinary practice, and agriculture have accelerated the development of resistant microorganisms. Today, infections caused by resistant pathogens claim millions of lives worldwide each year, with the World Health Organization warning of a postantibiotic era in which minor injuries or routine surgeries could again become life-threatening. Although AMR is often framed within the context of hospital-acquired infections and clinical treatment failure, its implications extend much further. In particular, AMR has significant consequences for physical and health fitness. For athletes, soldiers, patients in rehabilitation, and physically active individuals, resistant infections can disrupt performance, delay recovery, and compromise long-term health. The increasing prevalence of resistant organisms in community environments—including gyms, swimming pools, and sports facilities—further raises concern. This chapter situates AMR at the intersection of clinical medicine, sports science, and community health. It explores how resistant pathogens affect physically active populations, complicate rehabilitation processes, and influence outcomes in both competitive and recreational Fitnes. It also highlights the global and national responses to AMR, preventive strategies relevant to Fitnes and rehabilitation, and the role of healthcare professionals

Introduction
Antimicrobial resistance (AMR) is a critical public health problem globally, which can shake the foundation of modern healthcare. Infections caused by drugresistant organisms could lead to increased mortality and prolonged duration of hospitalization, causing a huge financial burden to the affected persons, healthcare systems and hinder the goals of sustainable development. With rising AMR, antibiotics are increasingly becoming ineffective for treating diseases.The post antibiotic era is not a dreadful imagination but a potential reality unless effective global actions are initiated now (1). AMR is not the only problem of human health, it widely affects the animal husbandry as well as environment. In India in 2019, there were 297,000 deaths attributable to AMR and 1,042,500 deaths associated with AMR. India has the 145th highest age-standardized mortality rate per 100,000 population associated with AMR across 204 countries.The number of AMR deaths in India is higher than deaths from neoplasms, respiratory infections and tuberculosis, enteric infections, diabetes and kidney diseases and maternal and neonatal disorders.Out of 10 million projected human deaths in 2050, one-fifth may be from India (2).Annually, more than 50 000 new-born are estimated to die from sepsis due to pathogens resistant to first-line antibiotics. The median cost of treatment of a resistant bacterial infection in India is estimated to be more than a year’s wages of a rural worker. There are five pathogens to be aware of in India (number of deaths associated with AMR in parenthesis): Escherichia coli (152,700), Klebsiella pneumoniae (123,200), Staphylococcus aureus (111,400), Acinetobacter baumannii (103,500), and Mycobacterium tuberculosis (98,600).If there is no timely containment, AMR is likely to cause nearly 10 million deaths by 2050 and resulting in significant economic losses. It would also impact nutrition security, livelihood and hinder the attainment of the Sustainable Development Goals. In 1928, penicillin was developed and socalled magic drug was subsequently commercialised and used globally. When antibiotic resistance ?rst emerged, novel antibiotics to treat these bacteria were developed. However, it is dif?cult to develop effective new antibiotics every time as it is time consuming and costly and if developed a new resistance mechanism emerges in bacteria. There is a demand for new strategies to treat bacterial infections, such as endophytes therapy, phage therapy, antimicrobial peptides, CRISPER cas and so on.

Objective: Preparation of Turmeric powder
Turmeric (Curcuma longa L), the ancient and sacred spice of India known as ‘Indian saffron’ is an important commercial spice crop grown in India. It is used in diversified forms as a condiment, flavouring and colouring agent and as a principal ingredient in Indian culinary as curry powder. It has anti-cancer and anti-viral activities and hence finds use in the drug industry and cosmetic industry. 'Kum-kum', popular with every house wife, is also a by-product of turmeric. It finds a place in offerings on religious and ceremonial occasions. A type of starch is also being extracted from a particular type of turmeric. The increasing demand for natural products as food additives makes turmeric as ideal produce as a food colourant. India is the largest producer, consumer and exporter of turmeric in the world.

1.1 Introduction
The concept of invention is the fundamental requirement for design thinking. Since the birth of mankind, people started inventing many concepts, which are mainly observations of facts and innovation of ideas for producing products that are useful to the society. The design thinking requires unconventional thinking to design processes for maximal operational efficiency of manufacturing the products, which give maximum satisfaction to customers with more value for money. Hence, the team that is involved in the design thinking projects may gain the required skills by knowing several inventions of the past. Hence, a review of inventions is presented in this chapter.
1.2 Tracing Inventions
The content at https://www.explainthatstuff.com/timeline.html gives a complete account of inventions starting from 4–5 billion years ago up to 2022. The article on solar cell energy gives an account of the sun started producing energy. About 1.2 million years ago, humans invented fire, which has been further innovated for biofuels, candles, IC engines, aviation engines, etc. In the 7th century B.C., ants were killed by burning in the heat produced by concentrated sun rays using magnifying lens. Greeks and Romans utilised burning mirrors to light candles during religious ceremonies in the third century B.C. About 3.5 million years ago, stone, wood, antlers, and bones were used by humans to make first kind of tools. These were further improved to make tools for machines. About 4000 BCE back, iron was used to make decorative ornaments. About 3500 BCE, people invented the concept of wheel, which brought quantum revolution in transportation.

harmony with nature is proving winner in the long run. If the past 60 years led to the Green Revolution in agriculture which often became Greed Revolution, the next 60 year should be the emergence of love for nature, diversity and Sustainable Green Revolution. The two goals – Sustainability and Productivity are inter-related. It is also said that the main difference between the past and today is that our problems are truly global. We are also aware that globally and nationally the rich-poor divide is growing and though world produces enough food, nearly 800 million people remain food insecure. Among 8 millennium goals, eradication of poverty and hunger and environmental sustainability are perhaps the most prominent and complimentary. In his book, “Remember your Humanity – Pathway to food Security”, M.S.Swaminathan has emphasized that a pro-nature, pro-woman and pro-livelihood orientation should be the bottom line of all technological development and delivery program for food security. Mainstreaming of environmental concern in agriculture to avoid exploitative agriculture and ecological consequence is therefore the call of the time.
COMPASSION
The great Tibetan scholar and close companion of HH Dalai Lama, Thupten Jinpa defines compassion as a mental state endowed with a sense of concern for the suffering of others and aspirations to see that suffering is relieved. One of the highest understanding underlined at the global level and in the preparation of sustainable development goals is for a hunger free world and for

Normally we associate our agriculture and food supply with farms and villages. The new trends of greener cities and urban and peri urban horticulture (UPH) are emerging very fast. Towns and cities in the world’s developing countries are growing at great speed. Ten years ago, an estimated 40 percent of the developing world’s population or 2 billion people lived in urban areas. Since then, their numbers have expanded twice as fast as total population growth, to more than 2.5 billion. By 2025, more than half the developing world’s population of 3.5 billion will be urban. Again most of the world’s fastest growing cities are in Asia and Africa with young population. The concept of “Green Cities” is being discussed for environmental sustainability. However, the core principles of Greener Cities can guide urban development that ensures food security, clean environment and economic well being. Urban and peri-urban horticulture, together with eco-friendly home and public gardens and sports fields can offer a solution for a better future.
Greener Cities and Eco Agriculture
FAO’s program for UPH is major initiative and the following advantages and plans taken from FAO’s report make the reasons clear : Urban and peri-urban horticulture (or UPH) is the cultivation of a wide range of crops - including fruit, vegetables, roots, tubers and ornamental plants - within cities and towns and in their surrounding areas. It is estimated that 130 million urban residents in Africa and 230 million in Latin America engage in agriculture, mainly horticulture, to provide food for their families or to earn income from sales. The FAO program have demonstrated how horticulture helps empower the urban poor, and contributes to their food security and nutrition. But it can