eBook Chapters

Mammary glands are important part of body which synthesize and store the milk in between milkings or suckling by the calf. Therefore it attains prime importance in any dairy animal. However, it has received little attention in buffaloes till now. Buffalo presents several unique characteristics in terms of milk production, length and shape of teats and arrangement of duct system in the mammary glands. Development of udder may be related to milk production and the knowledge of changes in its structure in relation to different physiological stages may also have practical implication.

Transducer Selection and Preparation of Scanning

Preparation of the site to be imaged will enhance the quality of the image. Therefore, any loose hair and dirt must be clean off. Ultrasound gel is applied to the area of interest. The gel acts as a coupling agent to prevent air from trapping between the transducer and skin. A 7.5 MHz transducer is ideal for imaging the teats. A 5.0 MHz transducer provides an adequate image. The mammary gland should be scanned with a 5.0-7.5 MHz transducer to give adequate penetration. All structures should be scanned in cross section and longitudinal planes.

Ultrasonography in sheep is becoming popular in the field of reproduction and replacing the other old-age techniques, viz. abdominal ballotment, recto- abdominal probes, X-rays and radioimmuno-assays. The reasons are numerous such as unsatisfactory results, hazardous effects to animal, operator or environment, high cost, long delay in diagnostic results and requirement of sophisticated labs. The ultrasound system has low operating cost and does not need special labs as it can be done at farm itself. Ultrasonography is considered safe to sheep and the operator and provides quick and reliable results. The popular opinion about ultrasonography is that it is noninvasive imaging system and is rapid, safe and practical means of diagnosis of pregnancy in sheep. The B-mode real time ultrasonographic system particularly portable system is popular among sheep breeders. In sheep, B-mode real time ultrasonography was used in 1971, using 5 MHz frequency transducer. A transducer of switchable frequency between 7.5 to 5.0 is more popular in sheep practice.

Transrectal Procedure in Sheep

The procedure is similar to goat, but sheep remain quite during transrectal ultrasonography than goat. Following are some of the steps to obtain good quality image:

Ultrasonographic images of stomach are required to diagnose ingestion of any abanormal materials by dog. When content of stomach are dry or there is gas in stomach then, it is difficult to get proper image of stomach. Offering water to animal or oral administration of water with the help of syring is also helpful in getting the images of content of stomach. Some time, while doing ultrasonography, movement of contents of stomach can be visualized. Stomach can be images between liver and spleen. The size depends upon contents or intake of food by dog. For proper image of gastrointestinal tract including stomach, there should not be gas in GIT. One should remember that ultrasound beam does not travel in gas. The best medium of ultrasound beam is liquid.

Scanning Technique

If possible, fasting for 12 hours is good to diminish the amount of gastrointestinal gas. However, non-fasted dogs, when offered water may show adequate image quality. The water may be administered in quantity of 15 ml per kg of bodyweight. Removing the stomach gas using an orogastric tube has been recommended tto enhance the visualization of lesions of the stomach, however, this is not in practice in India.

Ultrasonography in bull is helpful in diagnosis of problems of testis and accessory glands. This can also be used in assessment of development of these organs. Such developmental assessment, when combined with endocrine data, is useful to know age of puberty, sexual development and dimension of these organs. The ultrasonographic images and data are available for testis, bulbourethral gland, prostate and seminal vesicles in the bull. Ultrasonography of testis of bull can be useful to assess developmental changes, testicular dimensions and pathological conditions of the testis viz. tumors, lesions, abscess etc. Epididymis can also be examined for change in lumen, inflammation, granuloma etc. The accessory sex glands can be better viewed in ultrasonographic scanning to assess their dimensions, normal developmental changes and alterations in their morphology. Before, ultrasonography is undertaken, one should thoroughly revise the knowledge of sectional anatomy and location of these organs.

Testis

Location: The testis, in the bull, is located in the scrotum. In abnormal conditions, the testis might be retained in the inguinal canal or abdomen. Before, ultrasonography, location of the testis should be assured. For this, the testis should be palpated to assess their pliability and rule out adhesions with the scrotal wall. In normal condition, the testis should be freely movable in the scrotum, soft of palpation and both the testis should touch the bottom end of scrotum.

The Liver

The liver is a large and an irregular organ of the body, which extends from the sixth to the eleventh intercostal space. It extends much more caudally on the right side as compared to the left side. Its most caudal part is the caudate lobe whose small portion is visualized encircling the right kidney dorsally at the eleventh intercostal space. The liver of a dog is divided into various lobes namely the left lateral, left medial, quadrate, right medial, right lateral and the caudate lobes which are not identifiable ultrasonographically, except when f luid is present in the abdomen. Otherwise, the position of the different liver lobes can only be approximated. The gallbladder is located to the right of the midline between the quadrate and the right medial lobes of the liver.

Proper preparation of the animal is important to obtain images of abdominal orgnas including that of liver. It is better to keep animal off fed for at east six hours prior to ultrasound scanning. This will avoid interference of gases and solid contents of the gastrointestinal tract. If stomach is taken as landmark of scanning then enough fluid should be given prior to scanning to get good images of stomach. The liver can be easily visualized on one side of stomach. One should be liberal in applying good amount of gel over transducer and body for better image of liver.

Abstract

Application of ultrasound is one of the most promising uses of novel technologies in food processing. Use of ultrasound at various stages of drying has resulted in significant decrease in drying time and improvement in quality characteristics of dried products. The chapter discusses the principle behind use of ultrasound, general application in food industry with detailed description of various drying processes and equipments assisted by ultrasound.

ABSTRACT

Fruits and vegetables are rich source of bioactive compounds such as polyphenols, antioxidants and flavonoids. Drying is one of the common methods for preservation of food and agricultural commodities. However, drying may negatively affect the product quality attributes. This article is a capsule overview of current state of art ultrasound (US) assisted drying on technical aspects and bioactivity of fruits and vegetables. US assisted drying is an economical and sustainable technique compared to other existing conventional techniques used for food processing and preservation. US as a pretreatment before drying of agricultural-products enhances drying efficiency, inactivate enzymes and improve overall quality of dried products. Current developments and available solutions in drying have shown that US assisted drying may be used to restrict the loss of crucial bioactive components occurring naturally in fruits and vegetables. US when combined with hot air drying helps in achieving adequate drying rate at lower temperatures and improves overall dehydration process. This technique has found no practical application commercially due to various difficulties in achieving high-intensity US in air. One practical benefit of using US assisted drying is the minimization of the drying time along with reduction in total energy consumption.

Ultrasound is an excellent diagnostic modality for detecting visceral abnormalities. Detection of masses, nodules or effusions through sonography provides non-specific diagnosis. For specific/definite diagnosis tissue samples are necessary for histopathological examination. The techniques of ultrasound guided fine needle aspiration and core biopsy are of great help in establishing etiological diagnosis.

During last two decades significant advances have been made in diagnostic ultrasound .These advances have positively impacted on diagnostic imaging across all species of animals and have made ultrasound as an indispensable diagnostic modality in veterinary medicine. Since equines have been more a sport and pack animals, the ultrasound technique has long been utilized in the diagnosis of equine musculo-skeletal disorders. Recent years have witnessed its utility in the management of equine reproduction beside its use in the diagnosis of colic and other diseases.

Ultrasonography is being routinely practiced in canine and feline medicine for the diagnosis of diseases of the organs and also to confirm pregnancy. Its routine use in ruminant medicine is mainly restricted to pregnancy diagnosis. Recently the potential of ultrasonography is also being explored in zoo and wild animals as well as in exotic pets. Information available in companion and other domestic animals cannot be applied blindly to zoo and wild animals.

For the sake of convenience ruminants are broadly divided into two categories as large ruminants and small ruminants. Large ruminants consist of cattle and buffaloes and small ruminants consist of goats and sheep. Sonography is becoming an important part of diagnostic modalities in ruminants also. Its major use in ruminants is in reproduction and lameness.

Imaging of muscles, tendons, joints and bones is not common practice in canine and feline medicine. However, scanning of tendons and ligaments is extensively done in race horses to see their fitness. Adhesions, ruptures/ tears and inflammation of tendons and ligaments can be detected by sonographic imaging of these structures. These structures are relatively superficial so a high frequency linear or curvilinear transducer (7.5 to 13.0 MHz) is used to scan these structures. For scanning of joints acoustic window is relatively small so micro convex or sector probes are more appropriate.

Sonography of the nervous system in dogs dates back to 1972 when it was employed in experimental studies. Thick bony cage of the brain limits the sonographic evaluation of the brain. It has an important place in human paediatric medicine. Sonography of the brain and the nervous system is not very common in veterinary medicine.

Ultrasound and survey radiography are two important diagnostic modalities regularly employed in the diagnosis of intestinal diseases. Both modalities are complementary to each other in investigating the problems related to intestines. It is always better to have plain survey radiograph of abdomen first and then ultrasound to rule out obstruction or radio-opaque foreign bodies. Wherever barium meal radiograph is indicated, it should be done after sonographic examination as barium may degrade image quality of the sonogram. Assessment of intestinal motility can be done in real time sonography.

Liver is situated in cranial abdomen. Scanning of abdomen is started with the examination of liver. Hepatic ultrasonography is a non-invasive diagnostic modality to evaluate liver parenchyma. Differentiation of focal disease from diffuse disease, cystic lesions from solid masses, and obstructive jaundice from non-obstructive jaundice is possible by hepatic ultrasonography.

The pancreas is a thin and elongated ‘V’ shaped organ having two lobes (right and left) and body. It lies in the right cranial quadrant of the abdomen. It is difficult to visualize normal pancreas sonographically because of its echogenicity similar to that of adjacent mesentery and fat.

Application of ultrasonography has become a routine practice in canine and feline medicine to detect pregnancy, to ascertain foetal wellbeing, to ascertain live/dead status of the foetus, ovarian dynamics, and to diagnose reproductive ailments (uterine, ovarian,) in females. Sonography is also being preferred in males for the diagnosis of diseases of prostate gland, cryptorchid, and testicular diseases.

Spleen is an elongated solid organ located on the left side along cranial and ventral abdominal wall. The size of spleen is variable in dogs. The spleen is larger in German Shepherds and Greyhounds. In cats the spleen is smaller and has fixed size. It is parallel to greater curvature of stomach within greater omentum. The position of spleen in dogs is variable as it is only attached by gastrosplenic ligament.

Ultrasonographic examination of gastrointestinal tract is not very much rewarding in dogs because of gas in the tract but it is crucial for a correct diagnosis. Imaging of stomach plays a significant role in the diagnosis of gastric diseases such as gastric dilatation, gastric foreign bodies, pyloric outflow obstruction, or gastric tumours.

Beside heart, ultrasound of the thorax facilitates the imaging of lungs, pleura, mediastinum, chest wall and diaphragm. Sonographic examination of the heart is discussed in chapter16. Because of nearly total reflection of sound waves at gas interfaces (Fig. 176) thoracic ultrasound has limitations. Pulmonary and mediastinal lesions located deep are difficult to image. Peripheral pulmonary lesions and pleural fluid can be visualized.

Ultrasound has been used to image thyroid and parathyroid glands. It can assist in the diagnosis of hyperthyroidism and hyperparathyroidism in dogs and cats. Recently it has also been used to differentiate cases of primary hypothyroidism or euthyroid syndrome.

The urinary tract is the body’s drainage system. It includes kidneys, ureters, urinary bladder and urethra. Ultrasound is a most preferred imaging tool for the diagnosis of diseases of urinary tract not only in humans but also in dogs and cats. Little adipose tissue in urinary system of dogs makes the contrast between different planes and anatomical structures poor.

Veterinary ultrasonographer has to write report of ultrasonography in different animals. The proper ultrasound report writing is the moral duty of the vet ultrasonographer. The accuracy of diagnosis must be ensured. The poor resolution/quality of machine may lead to erroneous diagnosis. Therefore, veterinarian must ensure good quality of machine and proper diagnosis. The report might be different in different animals e.g. report writing about uterus will be different in bitch, cows, buffaloes, camel, horse, goat and sheep. However following might be guidelines in writing ultrasound report of uterus. fetus, endometrium

Uterus: Position of uterus, contents in the uterus, shape and size in initial pregnancy and infections, appearance of myometrium, thickening of uterine layers, presence or absence of fluied/pus/masses, left and right horns and their contents. Observations on the images of uterine fluid and its echoicity, membrane appearance in pregnant animals. Special attentions should be paid to endometrium.

Endometrium: Appearance and thickness; any growth on the surface of endometrium. Images of retained portion of placenta can be ascribed in the cases of retained placenta.

Ovary: Ovaries are scanned to assess cyclic structures, size, shape, its Position/ location and internal echo pattern of follicles. This echo pattern will indicate whether follicle is normal, cystic or with any other abnormalities of follclular f luid. Ultrasound reports also include shape and size of corpus luteum. In cows and buffaloes, presence of cavity, looseness/compactness of luteal cells are also mentioned.

Uncertainty : See information.

Underground economy : See black economy.

Underinsured : Refers to livestock which have some type of livestock health insurance, such as catastrophic care, but not enough insurance to cover all their health care costs.

Unemployment trap : When unemployed people who receive benefits, either from the goverment or from private charity, are deterred from taking a new job because the reduction or removal of benefit if they do will make them worse off. Also known as the poverty trap, it can be addressed, to an extent, by continuing to pay benefit for a while to unemployed people returning to work. (See welfare to work).

Unconventional feed ingredients are those feed ingredients that are less commonly used in formulations or whose nutritional properties and feeding value are less well understood. Hence, these feeds are not traditionally used for animal feeding either by farmers or by feed manufacturer.
Unconventional feed resources
Concentrates sources: These are mainly mangoseed kernel, neemseed cake, rubberseed cake, tamarindseed cake, tamarind seed kernel, tapioca waste, salseed cake, safflower cake, nigerseed cake, spent tea waste, mahua cake, karanj cake.
Tree leaves and fallen tree leaves: Banyan, peepal, mango, teak, bamboo, neem, gliricidia, banana, cassava, mulberry.
Other by-products: groundnut shell, paddy husk, maize cobs, bajra cobs, jowar cobs, husk of bengal gram, black gram, green gram, sugarcane tops, bagasse, water hyacinth, molasses etc.
Marine and aquatic waste: Fish waste, frog meal.
Starch industry waste: Maize germ, maize bran, maize gluten.
Brewery waste: Dried brewer’s grain (after extraction of malt)
Slaughter house by-product: Blood meal, meat meal, meat and bone meal, tankage.
Poultry industry by-product: Feather meal, offal meal/ poultry waste meal, hatchery waste.
High moisture agro-industrial by-products: vegetable and food processing residues, apple/tomato/pineapple pomace, citrus processing waste.

Sincehundreds ofyears, Livestockanimals arean integralpart ofcrop–livestock system. In the life style of Indian people, livestock had always been given a special and respectful place and this will continue in the years to come. Despite considerable deficit of feeds, the above may be one of the reasons of steadily increasing livestock production in our country. Almost all assessments made during the past eight decades, have shown deficits of different orders in respect of following for the availability of :

• Dry fodders

• Green fodders and

• Concentrates

Such surprising phenomenon is inviting our attention for reviewing systems of assessment for finding out the status of consumption and the gap between the above. Production of milk, meat, fibre, chicken and eggis increasing, though. Therefore, there is gap between the availability and requirements of different feeds. Because India is facing shortage of both protein and energy rich animal feeds, a large number of agro – forest based unconventional by products have been used. Some of these feeds were found to be promising, while others affected the performance of the animals, due to presence of incriminatingfactors present in them. But after detoxification, these feeds were suitable for animal feeding. Some of these feeds are :

Introduction

Organic substances consumed for nutritional purposes can be called as “food”. Food contains biomolecules, like, protein, lipid and carbohydrate, inorganic minerals as salts, and organic substances, such as, vitamins, emulsifiers, acids, antioxidants, pigments, polyphenols and flavour-producing compounds. They can be of plant or animal origin. Depending on the durability in terms of suitability of consumption, foods can be perishable, semi-perishable and non-perishable. Food spoilage occurs due to chemical, microbial, or physical actions. eventually affecting its nutritional values, colour, edibility and texture (M. Rahman, 2007).

Large number of edible fruits exists in tropics and subtropics of world. Many of such fruit species are identified, domesticated and are being utilized for various purposes, though their full potential has not been exploited. There is yet another group of plants producing edible fruits with great potential in different parts of world, which are not at all being grown and utilized by people other than in a very localized manner. Such under and un-utilized fruits are made the subject for detailed study. They are evaluated for their nutritive value, potential uses for other purposes, for possibilities of commercial cultivation in suitable areas and chances for marketing. Since all of them may not be acceptable for fresh consumption as table fruit, product diversification should be thoroughly evaluated to gain popularity for such plants. Practices and techniques employed for utilizing these fruits by local people where these plant species are seen at present can be scientifically and systematically refined for commercial exploitation.

Broad spectrum of agro climatic conditions and diversity in people’s preference for taste offer great chances to identify right fruit to a particular region for commercial cultivation in India. In this context, significance of under and un-utilized fruits for exploiting potentials become more clear. Identification of such plant species in different regions, extend and method of present utilization, nutritive value and pomological significance of the products, specific climatic and cultural requirements for successful growth and development should be documented as first step for exploitation of lesser known fruit species. Some of the under and un-exploited fruit species prevalent in tropical and subtropical conditions are discussed. In addition to this, attempt is made to incorporate an exhaustive list of plant species, which have potential for utilization as fruits and are rarely exploited at present. These are confined to only limited localities where people use produces for various purposes and are in most cases little known to other parts of world.

While setting up a garden or landscaping an area, the natural floristic wealth is ignored very often. But many of those flora are much adapted to prevailing soil and climatic conditions of the area. Plants with attractive flowers or foliage could be retained to maintain the natural appearance as well as to reduce cost of landscaping.Very familiar plants of our surroundings having good ornamental value are discussed in this chapter.

Goanese Ipecacuanha 
Naregamia alata commonly known as Goanese Ipecacuanha is a member of family Meliaceae. It is known as Tinparni in Hindi, Triparnika in Sanskrit, Nilanarakam in Malayalam, Nilanreagam in Tamil and Nelanaringa in Kannada. Common name was derived from its use of roots in treatment of malaria. Vernacular name, Nilanarakam originated from its morphological resemblance to members of Rutaceae. 

The seed spices are aromatic vegetable products mostly used in whole or ground form for imparting flavour, aroma and pungency to food. The seed spices possess industrial importance and are used in cosmetics, perfumery and pharmaceutical preparations.  The major seed spices , coriander, cumin, fennel and fenugreek are cultivated in larger areas in arid to semi-arid regions covering major parts of Rajasthan and Gujarat. Besides these four crops, a minor group of under exploited seed spices crops has tremendous scope for their cultivation in arid to semi-arid parts of the country. Such under exploited seed spice crops are ajowan, dill, celery, anise, caraway, black caraway, parsley and nigella.

India produces currently 8.4 lakh t. of seed spices from an area of  5.7 lakh ha. Owing to large domestic demand and stringent export regulations only 10% of total production is exported and earns a foreign exchange of Rs. 225 crores annually. The global demand of seed spices is 1,50000 t. and India  exports only 60750 t. annually. It is suggested that if wide range of seed spice crops are grown across the country, present level of production and export can be doubled. Therefore in addition to major group of seed spices, the minor seed spices, so called under exploited crops should be given emphasis and promoted amongst farmers for earning more profit through  export.

The biosphere or part of the earth and its atmosphere where life is found is made of different size of ecosystem regulated by solar energy. Ecosystems have both biotic and abiotic components. The biotic component comprises closely interacting groups of flora and fauna having varying energy needs which comprise heterotrophic, chemoautotrophic and photoautotrophic microorganisms.

Biodiversity refers to the richness of life as manifested by their morphological, cultural and biochemical characteristics of microorganism and their interdependence in habitat. It is because of biodiversity that each ecosystem functions as the basic life support system of the planet earth. Biodiversity sustains the food and nutrition security of human beings and mediates the ecological process by resisting environmental perturbations in a given soil and climatic conditions.

Presently greater emphasis is being placed on the biodiversity of above ground biotic components belonging to plant and animal kingdom. The living organisms in soil and their diversity in relation to their contribution to sustainable agriculture often do not receive adequate attention. Without taking into considerations the magnitude and understanding of the global diversity will be fragmentary. However, management of below ground biodiversity is being focused presently by several national and international bodies.

An auricle (pinna) and ear canal (external auditory meatus) of external ear play an important rolein the process of hearing. The main function if external ear is to collect vsound waves and divert them towards the middle and inner ear. The external ear I'd prone to different conditions along with inflammation, infections and other disorders. Common conditions of the external ear include otitis external, Carmen impaction. Contact dermatitis, external otitis media. Antibiotics, antifungal, corticosteroids, ear wax softener, analgesics are useful in treating the disordersof external ear. Finally it is concluded that the function of drugs on the external ear is related to a variety of therapeutic approaches aimed atvalleviating symptoms, resolving infections and increasing healing.

Introduction

The external ear, comprising the auricle (pinna) and the ear canal (external auditory meatus), plays a vital role in the process of hearing. While its primary function is to gather sound waves and direct them towards the middle and inner ear, the external ear is also susceptible to various conditions, including infections, inflammations, and other disorders. In such cases, medications are often employed to alleviate symptoms and treat underlying issues. Understanding how drugs interact with the external ear can shed light on their therapeutic mechanisms and potential side effects.

Aluminium is a ubiquitous metal and seen in an environment. Source of aluminium happens through dietary souce, food addivitives, packing materials, medications, environmental exposure as well as occupational exposure. Toxico kinetics is related to the interaction of aluminium with biological systems and toxicity also. Toxico dynamics of aluminium is related to the the oxidatve stress, neuro toxicity and bone toxicity. Diagnosis is based on MRI scan and measurement of serum as well as urine. Treatment is dependent on chelation therapy as well as avoidance of exposure. Finally it is concluded that aluminium toxicity leads to health risks in a significant manner along with potential adverse effects on neurological, gastro, intestinal, renal as well as skeletal systems.

Introduction

Aluminium is a ubiquitous metal observed naturally in the environment. It is widely used in various industrial and consumer products including cookware antacids, vaccines, and food additives. While aluminium is normally considered safe in low concentrations and exposure to high levels can lead to toxicity causing a range of adverse effects on human health. In this comprehensive article, authors will provide information regarding its toxicokinetics and toxicodynamics, clinical signs and symptoms, associated lesions, diagnosis and treatment strategies.

Antibiotics, often referred to as “magic bullets” in the battle against bacteria, stand out as one of the most remarkable medical breakthroughs of the 20th century. Their advent revolutionized the therapeutic landscape, consistently saving millions of lives from bacterial infections (WHO, 2020). Undoubtedly, antibiotics are a blessing to humanity, not merely for their medicinal applications but also for their diverse uses. They have long been employed in various contexts, including animal husbandry and production, serving as preventive measures in numerous underdeveloped and developing nations for decades (Majumder et al., 2020). A range of antimicrobial agents, including antibiotics, antifungals, antivirals, disinfectants, and food preservatives, function to either inhibit microbial growth or eradicate them altogether. Among these, antibiotics, specifically tailored to combat bacterial infections, are the most widely used class of antimicrobials. With their increasing and often improper use, microorganisms have developed antimicrobial resistance (AMR) (Murray et al., 2022).

Antimicrobial resistance is an inevitable evolutionary process observed in all microorganisms, and is driven by genetic mutations aimed at resisting the lethal pressures of selection. Bacteria, adapt to environmental selection pressures by developing resistance to antibacterial drugs, thereby diminishing the efficacy of these treatments (Murray et al., 2022). The widespread use of antibiotics, particularly in developing nations, further flares up the process, leading to significant repercussions such as increased rates of morbidity and mortality (WHO, 2020). The incidence and prevalence of antimicrobial resistant bacterial infections have reached alarming levels in the 21st century, posing a substantial threat to global public health akin to a silent pandemic. Antibiotic resistance knows no borders and can impact individuals of any age or gender, regardless of their location. In its present state, antimicrobial resistance (AMR) stands as one of the foremost threats, not only to global health but also to food security (Murray et al., 2022).

• In statistics, best linear unbiased prediction (BLUP) is used in linear mixed models for the estimation of random effects. BLUP was derived by Charles Roy Henderson in 1950 but the term “best linear unbiased predictor” (or “prediction”) seems not to have been used until 1962 (Henderson, 1975, 1985).

• “Best linear unbiased predictions” (BLUPs) of random effects are similar to best linear unbiased estimates (BLUEs) of fixed effects. The distinction arises because it is conventional to talk not about estimating fixed effects but rather about predicting random effects, but the two terms are otherwise equivalent.

BLUE and BLUP are both acronyms used in statistics

• BLUE stands for Best Linear Unbiased Estimates and refers to the solutions (or estimates) associated with the fixed effects of a model.

• BLUP stands for Best Linear Unbiased Predictions and refers to the solutions (but identified as predictions) associated with the random effects of a model.

• Both BLUEs and BLUPs are linear functions of the data and have the lowest variance.

• The expected value of a mean estimate for an individual equals its true value for BLUEs.

• BLUPs are similar to BLUEs, but it is conventional to talk about estimating fixed effects but predicting random effects.

• BLUP is the standard selection method in animal breeding where the breeding values of sires are estimated based on progeny performance to select superior genotypes and to breed superior families.

This chapter has focused on providing readers with a comprehensive understanding of business communication strategies and techniques in the Indian agricultural context. The chapter has highlighted the importance of communication in business, the challenges faced by the agricultural sector in India, and the need for effective communication strategies to overcome these challenges. The chapter has also provided an overview of relevant communication theories and techniques and their application in the Indian agricultural context. Understanding business communication is critical to developing effective marketing, supply chain, and other business-related strategies in the Indian agricultural context, and this chapter has laid a strong foundation for the same.

The Cerebellum plays an important role especially in coordinating voluntary movements as well as controlling balance. If Cerebellum is affected by abnormalities namely asynergia, these essential functions can be impaired, resulting in a significant difficulties regarding movement and coordination. Asynergia is related to lack of ability regarding coordination of muscle movements in a smooth manner, leading to Jerry or disjointed motions. The medications can modulate neuro transmitter activity, decrease symptoms namely tremors and rigidity and increase motor activity. Levpdopa is generally prescribed to decrease symptoms cerebellar abnormalities. Dopamine plays an important role in controlling movement and it's deficiency is implicated particularly in conditions namely Parkinsons disease, which can present with cerebellar dysfunction. Levodopa, frequently combined with carbi dopa to increase it's effectiveness, can help regarding an enhancement of motor activity and decrease tremors in patients with cerebellar disorders along with asynergia. Drugs that increase GABAnergic transmission, namely benzodiazepines and baclofen are generally used to manage symptoms namely spasticity associated with cerebellar abnormalities. Baclofen, a GABA _ receptor agonist, can decrease muscle spasticity and enhance coordination particularly in patients with cerebellar abnormalities. Anti cholinergic drugs namely trihexyphenidyl, can assist regarding reduction of symptoms namely tremors and rigidity by stopping the effects of acetyl choline. Dopamine receptor agonist namely pramipexole and ropinirole are useful regarding management of motor symptoms particularly in cerebellar abnormalities. Muscle relaxants namely tizanidine and dantrolene are used to decrease muscle stiffness and spasticity especially on patients with cerebellar abnormality. Finally it us concluded that pharmaco therapy can reduce symptoms and enhance quality of life for individuals with cerebellar abnormalities namely asynergia.

Constitution

The word ‘constitution’ is derived from a Latin word “Constituere” that means to set up or to make up or to establish. Therefore, it is the structure, composition, physical make up or nature of something consisting inherited qualities modified by environment. Constitution in homeopathy is defined as the physical and mental makeup which is expressed through physical built, characteristics, desires, aversions, reaction including emotional and intellectual attributes. In other words constitution incorporates the individual’s combined physical body type (including nervous system and metabolism), mental thinking, style, emotional reactivity and temperament.

Classification of constitution

Human constitution has been classified in different ways in different systems of health care.

The cerebellum plays an important role regard6 motor control, coordination and balance. If cerebellum experience dysfunction, it can result in various movement disorders, one of which is inhibition tremors. In the Cerebellum, GABAnergic neurons play an important role in modulating motor activities as well as coordination. By enhancing inhibitory neuro transmission, Benzo diazepines can assist on alleviating inhibition tremor symptoms. Baclofen is used to manage spasticity and can also provide relief especially for intention tremor. By blocking beta_ adrenergic receptors, propranolol reduces sympathetic nervous system activity, there. By reducing tremor activity

Pyrimidine, an anticonvulsant enhances GABAnergic neuro transmission. Targeted manipulation of gene expression within the Cerebellum mau offer more precise ND sustainable approach to manage inhibition tremor. Finally it is concluded that inhibition tremor, stemming from cerebellar disorder, exhibits significant challenges to individuals motor function as well as quality of life.

Introduction

The cerebellum, a critical structure located at the base of the brain, plays an important role in motor control, coordination and balance. When the cerebellum experiences dysfunction, it can lead to various movement disorders, one of which is inhibition tremor. Inhibition tremor is exhibited as an involuntary shaking or trembling of body particularly during voluntary movements, impairing fine motor skills and coordination. While there is no cure for cerebellar disorders, pharmacotherapy offers options to manage symptoms, including inhibition tremor.

Introduction

The economic cycle, also known as the business cycle, refers to the fluctuating state of an economy characterized by periods of economic expansion and contraction. It involves the cyclical pattern of growth and decline in economic activity, impacting various indicators like gross domestic product (GDP), employment rates, interest rates, and consumer spending2. The economic cycle is a fundamental concept in economics that helps determine the overall state of an economy as it moves through four distinct stages: expansion, peak, contraction, and trough. Understanding the economic cycle is crucial for investors, businesses, and policymakers as it influences investment decisions, business strategies, and economic policies based on the prevailing stage of the cycle.

1. Expansion

The upswing of the business cycle towards a peak is called an economic expansion. An economic expansion is associated with: Firstly, an increase in production and output is a prominent feature of economic expansion. This uptick in production signifies growing economic activity, as businesses ramp up their operations to meet rising demand.

Geographical Indications (GI) are indications or symbols that are affixed to products that possess a specific geographical origin and are known for their unique qualities or reputation. These products can be agricultural, natural, or manufactured goods that are essentially attributed to a particular region, locality, or country where they are produced. According to Article 22.1 of the TRIPS Agreement, GIs identify a good as originating from a specific territory, region, or locality, where a given quality, reputation, or characteristic of the good is essentially attributable to its geographical origin.

GIs are a product of collective tradition and decision-making and continue to evolve. They represent a combination of human effort, culture, land resources, and climatic conditions. GIs are limited to a specific region and are not transferable from one owner or region to another. A product that has a GI tag is associated with a specific geographical area where it is developed, and the GI sign on the product indicates its origin. Products designated with a GI acquire a high reputation and are valuable commercial assets for the geographical region where they originated. However, GIs are also exposed to misappropriation and forgery, and therefore require both national and international protection.

An accumulation of cerebro Spinal fluid (CSF) within the brains ventricles, leading to the enhancement of intra cranial pressure (ICP). This condition can happen at any age and may result from many underlying causes. Hydrocephalus can be congenital or acquired. Symptoms of Hydrocephalus include headache, nausea, vomiting, Gait disturbances, enlargement of the head in infants. Diagnosis is based on medical history, review, physical examination, Diagnostic tests and imaging studies namely MRI or CT scans. Differential Diagnosis include normal pressure Hydrocephalus, intea cranial hemorrhage and idiopathic intra cranial hypertension. Treatment is dependent upon ventricular shunt and endoscopic third ventriculostomy. Finally it is concluded that Hydrocephalus is a complex neurological condition along with diverse causes as well as presentations.

Introduction

Hydrocephalus, often referred to as “water on the brain,” is a condition manifested by the accumulation of cerebrospinal fluid (CSF) within the brain’s ventricles, resulting in the enhancement of intracranial pressure (ICP). This condition can happen at any age and may result from various underlying causes. Understanding its history, causes, symptoms, diagnosis, differential diagnosis and treatment is critical for effective management.

Diffusion research investigates the spread of ideas within social groups. It extends beyond the two-step flow theory by examining the factors that influence the adoption of innovations, which can include new ideas, products, or practices, among members of a culture. In multi-step diffusion, while opinion leaders still play a significant role in influencing adopters' behavior, there are also other intermediaries involved in the decision-making process between the media and the audience.

One such intermediary is the change agent, who persuades opinion leaders to either adopt or reject an innovation (Infante, Rancer, & Womack, 1997).

Innovations are not universally adopted by all individuals in a social system simultaneously; rather, adoption typically occurs over time and can be categorized into adopter categories based on the time it takes for individuals to start using the new idea. For change agents, identifying which category individuals belong to is highly practical, as their short-term objective often involves facilitating the adoption of an innovation.

The adoption of new ideas is driven by human interaction within interpersonal networks. When the initial adopter of an innovation discusses it with two members of a social system, and these two in turn influence two more peers, and so forth, the pattern of adoption follows a binomial expansion. Over time, the distribution of adopters tends to follow a bell-shaped curve (Rogers, 1971).

ABSTRACT

Concomitant with paradigm shift from agrarian and brick and mortar economy to knowledge and service based economy, India needs to adhere to the international conventions for the benefit of enriching its knowledgebase with which economic development and social welfare could be achieved. Although geoscientific research has been at the forefront and contributed immensely to our country’s economic development, number of applications for patents, copyrights, etc., on geoscientific concepts, databases, innovations, designs or processes has been negligible when compared with other branches of science. This paper intends drawing the attention of geoscientists on this lacuna and provides information on fundamental aspects of IPR that may be of help to geoscientists whose innovations are waiting to be filed for patents or copyright.

Mercury, a heavy metal, is present vi. Various forms and is well known for its toxic effects especially on human health. Mercury occurs naturally vin the environment through volcanic eruptions, weathering of rocks and forest fires. It can be observed in soil, water and the atmosphere. Human activities such as mining, industrial processes (eg. Coal Combustion, chor alkali production) and improper disposal of mercury containing products contribute to environmental contamination. Mercury can be absorbed through inhalation ingestion or skin contact. Once absorbed, mercury distributes throughout the body, crossing g the blood brain barrier and placenta. Inorganic mercury is partly metabolized to organic forms, such as methyl mercury, by micro organisms in environment. Mercury is excreted via Urine and feces. Mercury disrupts neuronal function by interfering with neurotransmitter signalling pathways, cognitive function, motor coordination and sensory perception Mercury accumulates in the kidneys, causing tubular necrosis. Proteinuria and renal failure. Clinical signs and symptoms are tremors memory loss, nausea, vomiting, hypertension and chest pain. Diagnosis is based on medical history, physical examination, blood, Urine, hair tests and neuro imaging techniques namely MRI or CT scans. Treatment is based on chelation therapy. Finally it is concluded that understanding the sources, toxico kinetics, toxico dynamics clinical manifestations and treatment options is critical for effective management and prevention of mercury toxicity.

Antibiotics serve as a backbone of modern clinical management but are currently facing serious threats from nosocomial and community emerging antimicrobial-resistance (AMR). The misuse and overuse of antibiotics and other antimicrobial agents in humans and animals have accelerated the development of resistant strains. Amongst the drug-resistant microbes, major threat is posed by the ESKAPEE group, an acronym for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., and Escherichia coli, comprising high to critical drug-resistant, World Health Organization Critical Priority I and II pathogens. The dry pipeline of effective and new antibiotics further exacerbates the situation with looming threat of heading to a ‘post-antibiotic era’. In such daring scenario of AMR, where AMR is expected to be the largest killer by 2050, it is imperative to understand the AMR development mechanism in bacteria as survival mechanism to find out way to mitigate AMR development and transfer.

As cherished members of our families, pet dogs bring joy, companionship, and unconditional love into our lives. Understanding their normal behavior is essential for building a strong bond and providing the care and support they need to thrive. Here’s a comprehensive guide to the typical behavior of pet dogs:

1. Social Behavior

• Dogs are social animals and thrive on companionship and interaction with humans and other animals. They often seek out attention, affection, and physical contact from their owners.

• Common social behaviors include wagging their tails, licking, leaning against their owners, and seeking proximity during rest or sleep.

Abstract

Plant-associated microorganisms play a significant role in conferring resistance to abiotic stresses. These organisms include rhizoplane and endophytic bacteria and symbiotic fungi and operate through a variety of mechanisms like triggering osmotic response and induction of novel genes in plants. The development of stress tolerant crop varieties through genetic engineering and plant breeding is essential but a long and strained process, whereas microbial inoculation to alleviate stresses in plants could be a more cost effective environmental friendly option which could be available in a shorter time frame. Considering the current trends available, intensive future research is needed in this area, particularly on field evaluation and application of potential organisms.

What is Panchgavya?
Panchgavya is an ancient, holistic preparation derived from cows, revered in Hindu culture for its spiritual, agricultural, and medicinal benefits. The term “Panchgavya” comes from Sanskrit, where “Pancha” means five and “Gavya” refers to products obtained from cows. True to its name, Panchgavya consists of five components sourced from cows: three primary ingredients (cow dung, cow urine, and cow milk) and two secondary ingredients (curd and ghee).
These ingredients are mixed in a specific proportion and allowed to ferment, creating a potent concoction. When applied in Ayurveda, this preparation is often referred to as “Cowpathy,” a traditional practice believed to harness the natural healing properties of cow- derived substances. In contemporary times, the uses of Panchgavya have extended beyond religious rituals to applications in agriculture, medicine, and even environmental conservation.
The Significance of Panchgavya
In Hindu traditions, cows are venerated as symbols of life and sustenance. As a result, the products derived from them hold immense cultural and spiritual value. Panchgavya is used in various rituals to purify spaces, offer prayers, and seek blessings. Beyond its spiritual aspects, Panchgavya has gained recognition for its practical benefits in multiple fields, particularly in organic farming, animal husbandry, and sustainable living.

Importance of Policies for Extension
Policies play an important role in the field of extension, which involves the transfer of knowledge and technology from researcher to farmers, communities and other stakeholders. Following are some specific reasons why policies are vital for extension:
1. Accountability: Policies may provide basis for monitoring and evaluation of extension activities and for holding extension professionals and other stakeholders accountable for their actions.
2. Innovation: Policies can promote innovation in extension by encouraging the adoption of new technology, approaches and practices, encouraging experimentation, collaboration and continuous improvement. By removing barriers to adoption and offering rewards for testing, policies can also aid in the creation of an atmosphere that fosters innovation.
3. Consistency: Policies aid in ensuring that extension activities are consistent with the goals and objectives of organization or program. It offers a framework for decision-making that enables the uniform
handling of similar circumstances.